نتایج جستجو برای: arachidonoyl dopamine

تعداد نتایج: 45801  

2016
Sally Miller Emma Leishman Olivia Oehler Laura Daily Natalia Murataeva Jim Wager-Miller Heather Bradshaw Alex Straiker

Purpose The diurnal cycling of intraocular pressure (IOP) was first described in humans more than a century ago. This cycling is preserved in other species. The physiologic underpinning of this diurnal variation in IOP remains a mystery, even though elevated pressure is indicated in most forms of glaucoma, a common cause of blindness. Once identified, the system that underlies diurnal variation...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Viviana Trezza Louk J M J Vanderschuren

The endocannabinoid system plays an important role in the modulation of affect, motivation, and emotion. Social play behavior is a natural reinforcer in adolescent rats, and we have recently shown that interacting endocannabinoid, opioid, and dopamine systems modulate social play. In the present study, we tested the hypothesis that, in contrast to administration of exogenous cannabinoid agonist...

Journal: :Molecular cancer therapeutics 2011
Koppany Visnyei Hideyuki Onodera Robert Damoiseaux Kuniyasu Saigusa Syuzanna Petrosyan David De Vries Denise Ferrari Jonathan Saxe Eduard H Panosyan Michael Masterman-Smith Jack Mottahedeh Kenneth A Bradley Jing Huang Chiara Sabatti Ichiro Nakano Harley I Kornblum

Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant subpopulation, here termed GBM stem cells, have been identified as primary therapeutic targets. Here, we describe a high-throughput small molecule screening approach that enables the identification and characterization of che...

Journal: :The Biochemical journal 1995
A Yamashita M Watanabe T Tonegawa T Sugiura K Waku

When [14C]arachidonoyl-CoA was incubated with crude extracts of rat liver microsomes, [14C]arachidonic acid was incorporated into many proteins, suggesting that modification of these proteins with fatty acid, i.e. acylation, occurred. Using a [14C]arachidonyl-CoA labelling assay, 50 and 53 kDa proteins were purified from rat liver microsomes to near homogeneity by sequential chromatography on R...

2018
Mohamed A. Zayed Fong-Fu Hsu Bruce W. Patterson Yan Yan Uzma Naim Malik Darwesh Gayan De Silva Chao Yang Clay F. Semenkovich

Patients with diabetes are at higher risk of developing carotid artery stenosis and resultant stroke. Arachidonoyl phospholipids affect plaque inflammation and vulnerability, but whether diabetic patients have unique carotid artery phospholipidomic profiles is unknown. We performed a comprehensive paired analysis of phospholipids in extracranial carotid endarterectomy (CEA) plaques of matched d...

Journal: :Journal of neurochemistry 2005
Gitte Petersen Birthe Moesgaard Patricia C Schmid Harald H O Schmid Helle Broholm Michael Kosteljanetz Harald S Hansen

The endogenous levels of the two cannabinoid receptor ligands 2-arachidonoyl glycerol and anandamide, and their respective congeners, monoacyl glycerols and N-acylethanolamines, as well as the phospholipid precursors of N-acylethanolamines, were measured by gas chromatography-mass spectrometry in glioblastoma (WHO grade IV) tissue and meningioma (WHO grade I) tissue and compared with human non-...

Journal: :Journal of lipid research 2010
Gabriela Montero-Moran Jorge M Caviglia Derek McMahon Alexis Rothenberg Vidya Subramanian Zhi Xu Samuel Lara-Gonzalez Judith Storch George M Carman Dawn L Brasaemle

Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an alpha/beta-hydrolase fold enzyme expressed in all vertebrates. The carboxyl terminus includes a highly conserved consensus sequence (HXXXXD) for acyltransferase activity. Mouse CGI-58 was expressed in Escherichia coli as a fusion protein with two ...

2011
Koppany Visnyei Hideyuki Onodera Robert Damoiseaux Kuniyasu Saigusa Syuzanna Petrosyan David De Vries Denise Ferrari Jonathan Saxe Eduard H. Panosyan Michael Masterman-Smith Jack Mottahedeh Kenneth A. Bradley Jing Huang Chiara Sabatti Ichiro Nakano Harley I. Kornblum

Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant subpopulation, here termed GBM stem cells, have been identified as primary therapeutic targets. Here, we describe a high-throughput small molecule screening approach that enables the identification and characterization of che...

Journal: :Zeitschrift fur Naturforschung. Section C, Biosciences 1985
I Flesch B Schmidt E Ferber

The fatty acyl specificity of phospholipase A1 and A2 in homogenates of mouse bone marrow-derived macrophages was determined using phosphatidylcholine and phosphatidylethanolamine of different acyl chain composition. Phosphatidylcholine with arachidonoyl at position 2 was cleaved preferentially by an alkaline phospholipase A2 (pH-optimum 9.0) leading to selective liberation of arachidonic acid....

Journal: :The Biochemical journal 1991
A M Bakken M Farstad H Holmsen

Apparent Km values have been determined for the substrates ATP, CoA and fatty acids for the long-chain acyl-CoA synthetase (EC 6.2.1.3) reaction in lysates of human blood platelets. The apparent Km for ATP was higher for saturated fatty acids (C12:0 to C18:0) than for unsaturated acids (C18:1 to C22:6). Other apparent Km values were very similar for all long-chain fatty acids tested. Palmitic a...

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