The debate on the influence of body temperature on morality and neurologic outcome of arrested patients has taken on reat significance since the recommendation in 2005 to lower core ody temperature to 32–34 ◦C as soon as possible after return of pontaneous circulation (ROSC).1 Therapeutic hypothermia (TH) hould become common practice in emergency medical services nd departments, though recent r...

This review summarises the findings of a series of studies in which the histological changes, induced in the reproductive system of Fasciola hepatica following treatment of the ovine host with the anthelmintic triclabendazole (TCBZ), were examined. A detailed description of the normal macroscopic arrangement and histological features of the testes, ovary, vitelline tissue, Mehlis' gland and ute...

Substituted quinolines (PQ code number), which reduce colony formation and increase gap junctional intercellular communication, were tested for their ability to interact with various molecular targets in murine and human tumor cell lines in vitro. Various markers of tumor cell metabolism, DNA fragmentation, mitotic disruption, apoptosis induction and growth factor receptor signaling pathways we...

Nuclear factor-kappa B (NF-kappa B) is an important transcription factor that regulates survival in many cells. Activated NF-kappa B has been shown to protect some haematopoietic neoplastic cells from apoptosis. In the present study, we analysed NF-kappa B status in 13 primary samples from patients with multiple myeloma (MM) and in four myeloma cell lines including U266, RPMI 8226, HS-Sultan an...

It is hard to imagine, given the wealth of new data reported over the recent past, that adipose tissue at one time was primarily considered as a passive reservoir for energy deposition and storage. However, research beginning in the early 1990s on the role of tumor necrosis factor (TNF)-a ushered in a new era of investigation, and since that time, there has been an incredibly rapid and substant...

The retinoblastoma (Rb) protein is a key regulator of cell proliferation, differentiation, and tumorigenesis. Initial studies of Rb revealed that it binds to, and decreases the activity of, the E2F family of transcription factors. Over the last decade, the mechanisms by which Rb regulates E2F activity have been well-studied. These investigations have lead to a commonly held belief that Rb funct...

The antioxidation capacities of green ‘Welcome’, green and white ‘Gijnlim’, and purple ‘Purple passion’ asparagus spears were evaluated. Analyses of rutin and total polyphenols, and assays of DPPH radical absorbing and low-density lipoprotein (LDL) antioxidation were conducted. Varietal differences associated with the colors of spears were observed both in the amounts of rutin, total polyphenol...