نتایج جستجو برای: apoptotic genes
تعداد نتایج: 470166 فیلتر نتایج به سال:
Psoriasis is a common autoimmune skin disease. The aim of this study was to investigate whether the apoptotic process is disturbed in psoriatic keratinocytes. In vitro culture of keratinocytes derived from both involved and uninvolved psoriatic skin, revealed higher viability and resistance to apoptosis following exposure to ultraviolet B, compared with cells from healthy controls. The position...
Abstract Background An extract of Ficus religiosa latex has been previously found to possess potent pharmacological activity with high antioxidant content phytochemical. The present research was conducted investigate the chemo-preventive efficacy on human breast adenocarcinoma MDA MB 231, neroblastoma IMR 32, and colorectal HCT 116 cell lines. Results results showed that crude induced cytotoxic...
The transcription factor NF-κB is important for expression of genes involved in immune responses, viral infections, cytokine signaling and stress. In addition NF-κB plays a crucial role in protecting cells from TNFα-induced apoptotic stimuli, presumably by activating anti-apoptotic genes. Here we report that the substoichiometric TFIID subunit TAFII105 is essential for activation of anti-apopto...
It is well established that during the execution of the apoptotic cascade, activated caspase 3 releases sterol regulatory element-binding proteins (SREBP) from the membrane of the endoplasmic reticulum in a proteolytic reaction that is distinct from their normal sterol-dependent activation. However, it is not known whether these transcription factors are capable of activating sterol-responsive ...
Edwardsiella tarda is a pathogen with a broad host range that infects both animals and humans. Resistance to phagocytic killing may be involved in the pathogenicity of this bacterium. Here we show that intracellular replication of E. tarda in murine macrophages is dependent on the type III secretion system and induces an anti-apoptotic effect by up-regulating anti-apoptotic NF-κB target genes. ...
Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors. The screening of three different cDNA libraries prepared from metastatic melanoma, glioblastomas and leukemic blasts allowed for the identification of many yeas...
Background: Halophilic microorganisms have the potential to produce new biomolecules, including anti-cancer compounds, for medical applications. The purpose of this study was to evaluate the anti-cancer properties of pigments extracted from native Iranian halophilic Archaeon. Materials and Methods: Pigment extract of Haloarcula sp. previously isolated and identified from Aran-Bidgol Lake was e...
gastric adenocarcinoma is a common malignancy with high rate among other cancers in the world and many ethological causes have been introduced for which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. this agent is also associated with more different digestive diseases, such as gastritis, peptic ulcer, mucosa-associated lym...
Prostate cancer is the most commonly diagnosed and second leading cause of mortality in men Western World. In initial stages, prostate dependent on androgens for growth which basis androgen ablation therapy. The effects are mediated by Androgen Receptor (AR). Therefore, studies focus identification AR-regulated genes that also highly expressed prostate. STAMP family STAMP1/STEAP2 STAMP2/STEAP4 ...
Nobiletin is considered a phyto-flavonoid extracted from citrus peel and shown to several pharmacological roles such as anti-inflammatory, anti-tumor neuroprotective properties. In this study, we investigate the role of nobiletin combined docetaxel enhances apoptosis in colorectal cancer cell lines. Our results confirmed enhanced docetaxel-induced reactive oxygen species generation human carcin...
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