The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients and controls were investigated and compared, and the composition...

BACKGROUND AND PURPOSE The association between apolipoprotein E (apoE) polymorphisms and stroke has been controversial. These controversies may be due to inaccurate classification of stroke and differences in age ranges. We investigated the association between apoE genotypes and stroke subtypes (confirmed by CT or MRI findings) by case-control study in a Japanese rural population. METHODS Fir...

BACKGROUND Previously, the epsilon 4 allele of apolipoprotein E (APOE) was reported to have a significant association with a decreased risk of age-related macular degeneration (AMD). In addition, the epsilon 2 allele of APOE was reported to be possibly associated with an increased risk of AMD. OBJECTIVE To determine if APOE polymorphisms, previously reported to be associated with AMD, affect ...

BACKGROUND APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations. METHODS We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive functi...

The aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defined as age at the first unequivocal seizure (excluding febrile convulsions)....

OBJECTIVES Previous studies have shown the impact of angiotensin converting enzyme (ACE) insertion/deletion (I/D), endothelial nitric oxide synthase (eNOS) polymorphisms and ApoE genotypes on coronary artery disease (CAD). The aim of this study is to investigate the relationship between the genetic polymorphisms and the severity of CAD and to evaluate their potential interactions. MATERIAL AN...

Objective. To study the polymorphisms of genes involved in angiogenesis and metabolic processes, to assess level lymphocytes patients with chronic endometritis practically healthy women reproductive period.
 Materials methods. 86 were examined; DNA regions eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) used as primers; blood (CD3+, CD4+, CD8+, CD...

Abstract Background To determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy. Methods In total, 352 patients before after treatment 48 healthy individuals were enrolled in this study. detected by Quantimetrix Lipoprint System. The 11 gene polymorphisms— HTR3B (rs2276307, A > G), APOE (rs7412, c.526C T), (rs429358, c.388 T C), CYP2C9*3 (rs1057910, c.1075A ...

OBJECTIVE To examine the individual and combined associations of ApoE and MTHFR 677C/T polymorphisms with cognitive performance in adolescents. STUDY DESIGN The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability. RES...

BACKGROUND AND PURPOSE Cerebral amyloid angiopathy (CAA) is common in the ageing brain and is associated with dementia and lobar intracerebral haemorrhage. We systematically reviewed genetic associations with CAA to better understand its pathogenesis. METHODS We comprehensively sought and critically appraised published studies of associations between any genetic polymorphism and histopatholog...