OBJECTIVES It has been demonstrated that the deleterious effect of smoking on the cardiovascular system is mediated through a decrease in protective HDL cholesterol. In addition, women are more sensitive to the negative effects of smoking, although the exact mechanism underlying this phenomenon is currently unknown. In this study, we evaluated whether smoking habits could modify the association...

Aims: The objective of the study was to determine clinical utility different ratios serum lipid and apolipoprotein as predictive markers for diabetic retinopathy (DR). Methodology: In this case control study, participants were divided in four groups, normal controls, non-proliferative (NPDR) proliferative (PDR). Staging done based on fundoscopy by an ophthalmologist. A fasting venous blood assa...

schizophrenia is a mental disorder painful with prevalence of about 1% in the world.  nowadays, there is no experimental test aiding the accurate diagnosis of schizophrenic patients but recently quantitative determination of some serum proteins led to many investigations on the roles of these in neuropsychiatric.in the present study, our aim is to quantitative determination apoa1 and igm betwee...

In the present work we investigated HDL-C and its subfractions HDL2 and HDL3 as well as total cholesterol (TC), triglycerides (TG), LDL-C, VLDL-C, apolipoproteins A1 (ApoA1) and B (ApoB) and lipoprotein (a) (Lp(a) in 25 patients with newly diagnosed acute lymphocytic leukemia (ALL) before and after induction treatment. The mean basal plasma levels of TC, HDL-C and its subfractions, LDL-C, and A...

Spherical high density lipoprotein (sHDL), a key player in reverse cholesterol transport and the most abundant form of HDL, is associated with cardiovascular diseases. Small angle neutron scattering with contrast variation was used to determine the solution structure of protein and lipid components of reconstituted sHDL. Apolipoprotein A1, the major protein of sHDL, forms a hollow structure tha...

BACKGROUND Traditional lipid indices have been associated with type 2 diabetes, but it remains uncertain which lipid index is the best discriminator for diabetes. In this study, we aimed to assess lipoproteins, traditional lipid variables, and other variables to discover their association with diabetes in the Taiwanese population. METHODS Data from a nationwide cross-sectional population-base...

The copolymer surfactant poloxamer 407 (P-407) has been used to induce a dose-controlled dyslipidaemia in both mice and rats. Human macrophages cultured with P-407 exhibit a concentration-dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) due to down-regulation of the ATP-binding cassette transporter A1 (ABCA1). Peroxisome proliferator-activated receptor alpha (PPARalpha) ca...

The plasma cholesteryl ester transfer protein (CETP) plays a major role in the catabolism of HDL cholesteryl ester (CE). CETP transgenic mice have decreased HDL cholesterol levels and have been reported to have either increased or decreased early atherosclerotic lesions. To evaluate the impact of CETP expression on more advanced forms of atherosclerosis, we have cross-bred the human CETP transg...

OBJECTIVE To investigate whether the risk profile of coronary heart disease (CHD) is more favorable in physically active men with tetraplegia compared with sedentary men with tetraplegia. DESIGN Using a cross-sectional design, the lipid and (apo)lipoprotein concentrations of 11 active and 13 sedentary men with tetraplegia were compared. Regression analysis was applied to investigate the influ...

Since data regarding the relationship between a common polymorphism (SNP) of the apoA1 gene with apoA1 levels and risk of coronary artery disease are inconsistent, we hypothesized that its association with recurrent coronary events differs for White and Black individuals with diagnosed coronary heart disease. The apoA1 -75G>A SNP was genotyped in a cohort of 834 Black (n=129) and White (n=705) ...