In the accompanying editorial, Sniderman and Silberberg raise the question, "Is It Time To Measure Apolipoprotein B"? If this question means whether it is time to measure apolipoprotein B-100 (apo B) clinically to estimate the risk for coronary heart disease (CHD) or to guide in lipid-lowering therapy, our answer is an unqualified "No." Whether measurement of apo B will prove valuable in the fu...

In the accompanying editorial, Sniderman and Silberberg raise the question, "Is It Time To Measure Apolipoprotein B"? If this question means whether it is time to measure apolipoprotein B-100 (apo B) clinically to estimate the risk for coronary heart disease (CHD) or to guide in lipid-lowering therapy, our answer is an unqualified "No." Whether measurement of apo B will prove valuable in the fu...

Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to the APO-1-dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the ...

In the accompanying editorial, Sniderman and Silberberg raise the question, "Is It Time To Measure Apolipoprotein B"? If this question means whether it is time to measure apolipoprotein B-100 (apo B) clinically to estimate the risk for coronary heart disease (CHD) or to guide in lipid-lowering therapy, our answer is an unqualified "No." Whether measurement of apo B will prove valuable in the fu...

In the accompanying editorial, Sniderman and Silberberg raise the question, "Is It Time To Measure Apolipoprotein B"? If this question means whether it is time to measure apolipoprotein B-100 (apo B) clinically to estimate the risk for coronary heart disease (CHD) or to guide in lipid-lowering therapy, our answer is an unqualified "No." Whether measurement of apo B will prove valuable in the fu...

Apolipoproteins are proteins associated with lipids in lipoprotein particles. They play important roles in lipoprotein metabolism, such as transport of these hydrophobic molecules in plasma aqueous medium, binding to specific receptors in cell surface to correctly direct lipids to target organs and body tissues, and activation or inhibition of enzymes involved in lipid metabolism. Apolipoprotei...

We investigated the immunoprecipitation of apolipoprotein B-binding lipoproteins, or of apo A-I- and apo C-binding lipoproteins, by delipidated antiserum for measuring cholesterol in the nonprecipitated lipoprotein fractions. After immunoprecipitation of serum with delipidated anti-apo B, we determined by immunoelectrophoresis that no beta- or pre-beta lipoproteins were present, whereas alpha-l...

Triglyceride-rich lipoprotein apoprotein catabolism was studied in rats from 5 to 60 min after intravenous injection of 125I-labeled lipoproteins. The plasma and liver labeled apoprotein content was analyzed by gel filtration column chromatography using an elution buffer containing 1% sodium dodecyl sulfate. The method resolved two B apoproteins of lower (apo B1) and higher (apo Bh) molecular w...