BACKGROUND Aplastic anemia is a rare and severe disease. Its incidence varies considerably worldwide. We aimed at describing the epidemiology of this disease, including the incidence, mortality and survival trends, in a well-defined population. DESIGN AND METHODS Since 1980, a case-control surveillance study of aplastic anemia has been carried out by a cooperative group, in the metropolitan a...

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Cyclosporine (CyA) therapy has been shown to be effective in some patients with aplastic anemia. In an attempt to characterize aplastic patients likely to benefit from CyA therapy, we examined bone marrow mononuclear cells (BMMC) obtained before therapy from 23 patients with aplastic anemia, who were treated with CyA alone. Expression of four myelosuppressive cytokines, including tumor necrosis...

Frickhofen, N. & Rosenfield, S.J. (2000) Immunosuppressive therapy of aplastic anaemia with anti lymphocyte globulin and cyclosporine. Seminars in Haematology, 37, 56–68. Meletis, J., Samarkos, M., Mesogitis, S., Melitis, C., Mougiou, A., Terpos, E., Tsimberidou, A., Andreopoulos, A., Konstantopoulos, K. & Loukopoulos, D. (1998) Severe aplastic anaemia relapsing during a pregnancy; spontaneous ...

We carried out chromosomal analysis of a 33-year-old male who was diagnosed as having aplastic anemia. The patient showed severe pancytopenia, a normal NAP score, hypoplastic marrow and no myelodysplastic changes. 45,XO was found in all bone marrow cells examined, and in 10% of peripheral blood cells examined. To our knowledge, this is the first reported case of male aplastic anemia to show los...

P ROGNOSIS in aplastic anemia has improved since the introduction of testosterone therapy.1 This androgenic hormone has proved very useful in the treatment of children with congenital and acquired aplastic anemia,1-5 but appears to be less effective in adults with the same disorder.#{176} Oxymetho1one79 and other related steroids4’1015 have recently been used in place of testosterone with good ...

CONTEXT The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CAS...

Aplastic anemia is not an uncommon disorder. Estimated frequency is 3-6 per million populations per year. Occurrence of aplastic anemia however, concurrently with pregnancy in a previously healthy woman is a rare phenomenon. Since 1888 when it was first described not more than a handful of cases have been reported in literature. Pregnancy associated with marrow aplasia poses great problems for ...

1483 telomere shortening and provides no evidence for haematopoietic stem cell exhaustion. Br J Haematol 2002;116:491-6. 7. Vulliamy T, Marrone A, Goldman F, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 2001;413:432-5. 8. Vulliamy T, Marrone A, Dokal I, Mason PJ. Association between aplastic anaemia and mutations in telomerase RNA. Lance...