Tools support has an important role to play in teaching aspectoriented programming (AOP) by making the crosscutting structure of AOP programs explicit. In this paper we discuss lessons learned from introducing many developers to AOP for the first time, and from developing the AspectJ Development Tools (AJDT) [1] support for Eclipse [2]. To address those lessons we also discuss future plans for ...

More and more software projects are using COTS (commercial-off-the-shelf) components. One of the most challenging problems in COTS-based development is to evolve a system to follow changes in the customer requirements. It is therefore important to increase the changeability of the COTS-based system, so that new component can easily replace the problematic COTS components. Aspect-Oriented Progra...

BACKGROUND Earlier age at onset of psychosis (AOP) has been associated with poor social adjustment and clinical outcome. Genetic and environmental factors such as obstetric complications, parental history of psychosis, advanced paternal age at time of birth, low birth weight and gestational age, and use of drugs have been described as bringing AOP forward. This study aims to evaluate the relati...

Abrin A-chain (ABRA) inhibits protein synthesis by its N-glycosidase activity as well as induces apoptosis, but the molecular mechanism of ABRA-induced cell death has been obscure. Using an ABRA mutant that lacks N-glycosidase activity as bait in a yeast two-hybrid system, a 30-kDa antioxidant protein-1 (AOP-1) was found to be an ABRA(E164Q)-interacting protein. The interaction was further conf...

One of the issues in software evolution is debugging. Debugging large and complex software systems evolved requires a lot of effort since it is very difficult to localize and identify faults. Therefore, reducing the effort of debugging process is an important step towards efficient software evolution. Program slicing, especially dynamic slicing, has been proposed to efficiently localize faults ...

In [9] we defined the concept of agent oriented programming (AOP), which can be viewed as a specialization of object oriented programming (OOP). AOP views objects as agents with mental state, and, in the spirit of speech act theory, identifies a number of message types informing, requesting, offering, and so on. AOP is a general framework. In this paper we present a specific and simple language...

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic understanding. The adverse outcome pathway (AOP) framework provides a systematic approach for organ...

This document is an overview of formal models for AOP. It covers most existing formalisms. Instead of explaining the technical details of each work, we identify key concepts for AOP, and mention how they are modeled.

Objective COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structure...