Aim: The overall aim of this thesis was to explore psychosocial consequences on children with high and intermediate imperforate anus and their parents. Material/Methods: Paper I was an explorative study involving interviews. The purpose was to illuminate the children’s and parents’ experiences of imperforate anus (IA) and to create a baseline for further research. In Papers II-V, study-specific...

BACKGROUND Human papillomavirus (HPV) is a causative factor in squamous cell carcinomas of the anus, penis, vagina, vulva, and head and neck, and adenocarcinoma of the cervix. We examined the demographics, clinical characteristics, and timing of multiple potentially HPV-related cancers in individual patients. METHODS One hundred forty-three patients were identified with 300 potentially HPV-re...

Ectopic anus is an atypical uncommon variant of broad spectrum of anorectal malformation. We present a case of a 22 day old neonate with anus placed within scrotum. After surgical intervention a neoanus was created within sphincter complex and good functional result was achieved. Patient had urethral injury intraoperatively which was managed by urethrostomy. Subcoronal hypospadias and urethrost...

Aim: To evaluate the usefulness of counting nucleolar organiser region associated proteins (AgNORs) in the management of anal squamous neoplasia. Method: Using a silver staining technique for NOR associated proteins, 32 routinely processed paraffin wax embedded sections of anal epithelium were assessed. These consisted of normal anal epithelium (n = 9), anal intraepithelial neoplasia (AIN) grad...

Squamous cell anal cancer remains an uncommon entity; however, the incidence appears to be increasing in at-risk populations, especially those infected with human papillomavirus (HPV) and human immunodeficiency virus (HIV). Given the ability to cure this cancer using synchronous chemoradiotherapy, management practices of this disease are critical. This article considers treatment strategies for...