For thyroid hormone synthesis, thyroid peroxidase (TPO) molecules must be transported from the endoplasmic reticulum via the Golgi complex to be delivered at the cell surface to catalyze iodination of secreted thyroglobulin. Like other glycoproteins, TPO molecules in transit to the cell surface have the potential to acquire endoglycosidase H resistance as a consequence of Golgi-based modificati...

Autoimmune thyroiditis is one of the most common causes acquired hypothyroidism in children and adolescents. Both genetic susceptibility environmental factors play a role etiopathogenesis. We report two cases autoimmune here with varied presentation. them had different clinical features at On investigation, both elevated thyroid-stimulating hormone (TSH), low T4 anti-Thyroid peroxidase (TPO) an...

objective: diabetes mellitus and thyroid disease are the two common endocrinopathies seen in adult population. studies to evaluate thyroid disorders in patients with type 2 diabetes are lacking. the aim of this study was to compare prevalence of thyroid dysfunction and autoim-munity in type 2 diabetic patients with age and sex matched non-diabetic control group. material and methods: among pati...

Objective The tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). The aim of this study was to evaluate whether thyroid autoimmunity is higher in BTM. Methods Patients with BTM (n=86) and a healthy control group (n=93) were included in this cross-sectional case-control study. The two groups were compared in terms of anti-thyroglobulin (anti-TG) a...

Hashimoto's thyroiditis, a common autoimmune disease, is associated with autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO). TPO, unlike abundant and easily purified Tg, is rarely investigated as an autoantigen in animals. We asked whether antibodies (Abs) develop to both TPO and Tg in thyroiditis that is induced (C57BL/6 and DBA/1 mice) or arises spontaneously (NOD.H-2h4 mice). ...

A full-length cDNA clone for human thyroid peroxidase (TPO) inserted into the mammalian cell expression vector pECE was stably transfected into Chinese hamster ovary (CHO) cells. Clones were assayed for human TPO mRNA, TPO protein, and TPO enzymatic activity. One subclone, expressing the highest TPO enzymatic activity, was used in further studies. FACS analysis of these cells preincubated in Ha...

BACKGROUND The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE The aim of the present study was to define the prevalence of anti-thyroid peroxidase (TPO) antibodies and autoimmune thyroiditis in children and adolescents with...

Hashimotos encephalopathy is an autoimmune disorder, with high titres of antithyroid peroxidase antibody, usually with a clinically and biochemically normal thyroid function. Here we present a case of hashimotos encephalopathy in a 34yr old man, who presented with acute onset of cognitive impairment on a background of psychiatric illness. Initially a probability of neuroleptic malignant syndrom...

conclusions high prevalence of thyroid antibodies in euthyroid patients with pcos refers to the importance of investigation for thyroid autoimmune state in those patients. objectives the aim of this study was to evaluate the prevalence and levels of thyroid antibodies in euthyroid women with pcos in syria. patients and methods this study included 56 euthyroid women with pcos and 30 healthy wome...

Destruction-induced thyrotoxicosis includes various painful diseases such as subacute granulomatous thyroiditis, acute exacerbation of chronic thyroiditis and acute suppurative thyroiditis. In contrast, the clinically painless form of destruction-induced thyrotoxicosis is almost exclusively restricted to painless or silent thyroiditis. We report what we believe to be a case of acute exacerbatio...