Schizophrenia is associated with brain glutamate dysfunction, but it is currently unclear whether antipsychotic administration can reduce the extent of glutamatergic abnormality. We conducted a systematic review of proton magnetic resonance spectroscopy (1H-MRS) studies examining the effects of antipsychotic treatment on brain glutamate levels in schizophrenia. The Medline database was searched...

OBJECTIVE We report 3 cases of intraoperative floppy-iris syndrome (IFIS) during cataract surgery in patients without a history of selective α1-blocker use but with a long-term history of antipsychotic drug use. We reviewed previously reported cases of antipsychotic drug-associated IFIS cases. DESIGN Observational case series. RESULTS In case 1, bilateral IFIS developed in a 39-year-old man...

BACKGROUND Atypical antipsychotic augmentation was demonstrated to be efficacious in treatment-resistant depression (TRD) in previous meta-analyses. We investigate whether there are differences in the effect size of atypical antipsychotic augmentation in major depressive disorder according to the degree of treatment resistance. METHODS A comprehensive search of four databases identified 11 ra...

BACKGROUND Antipsychotic medications are commonly prescribed to nursing home residents despite their well-established adverse event profiles. Because little is known about their use in Veterans Affairs (VA) nursing homes [ie, Community Living Centers (CLCs)], we assessed the prevalence and risk factors for antipsychotic use in older residents of VA CLCs. METHODS This cross-sectional study inc...

Antipsychotic treatment can produce supersensitivity to dopamine receptor stimulation. This compromises the efficacy of ongoing treatment and increases the risk of relapse to psychosis upon treatment cessation. Serotonin 5-HT2 receptors modulate dopamine function and thereby influence dopamine-dependent responses. Here we evaluated the hypothesis that 5-HT2 receptors modulate the behavioural ex...

Atypical antipsychotic medications have been the first line of treatment for adolescents with psychosis in the past couple of decades. Till the late 90s, there were very few randomized controlled trials (RCTs) on the treatment of adolescents with psychosis, although a fifth of schizophrenia starts during adolescence. Most of the treatment guidelines for adolescents with psychosis were derived f...

traditionally, schizophrenia was considered to be a severe psychiatric disorder, with a chronic course and an unfavorable outcome. throughout history, there has been incidence of schizophrenia, roughly one percent of the population, consistently, in every culture. it is generally acknowledged that schizophrenia has multifactorial etiology, with multiple susceptibility genes interacting with env...

treatment of tuberculosis was an obstacle for ages. in spite of good drugs, the disease is not under control. thus, the need for more drugs existed. searching for a new drug demands much investment on the time, money and human resources. there are many drugs with antitubercular action that are discovered and explored in the last century. the most common drug, isoniazid, is now a frontrunner ant...

Introduction The use of antipsychotics in the treatment mentally ill represents a complex modality, especially specialized institutions such as Institute Forensic Psychiatry Kosovo. Current best practices are summarized clinical guidelines, which nevertheless recognize importance individualizing treatment. In literature there is scarcity knowledge on effectiveness pharmacological within forensi...

Repeated administration of haloperidol (HAL) and olanzapine (OLZ) causes a progressively enhanced disruption of the conditioned avoidance response (CAR) and a progressively enhanced inhibition of phencyclidine (PCP)-induced hyperlocomotion in rats (termed antipsychotic sensitization). Both actions are thought to reflect intrinsic antipsychotic activity. The present study examined the extent to ...