BACKGROUND Cyanate is a uremic toxin formed principally via spontaneous urea biodegradation. Its active isoform, isocyanate, is capable of reaction with proteins by N and S carbamoylation, which influences their structure and function. Sulfurtransferases implicated in anaerobic cysteine transformation and cyanide detoxification belong to the enzymes possessing SH groups in their active centers....

Iron nanoparticles (Fe NPs) have a wide array of biological and medical applications. In agriculture, Fe NPs has the potential to be used as an innovative technique alleviate deficiency in various crops, such grape. However, effect on alleviating stresses grapevine are unexplored. The aim this study was evaluate efficiency protecting ‘Asgari’ seedless grape (Vitis vinifera L.) against oxidative...

Antioxidants are primarily responsible for the beneficial health effects of foxtail millet. This study evaluated a foxtail-millet-based composite antioxidant nutritive flour consisting fermented millet, coarse grains, and fruit powders. The composition was optimized, it found to be rich in nutrients, such as phenolics (2.27 g/100 g), vitamin C (0.21 polysaccharides (0.35 g). results revealed th...

Aims: Cyclophosphamide (CP) is a broad-spectrum chemotherapy agent available to treat various malignancies; however, its nephrotoxicity limits clinical use. Formononetin (FOR) bioactive isoflavone with encouraging biological activities. The current study explored and elucidated the possible protective/therapeutic effects of formononetin against CP-induced nephrotoxicity.
 Methodology: Rats...

BACKGROUND This investigation describes the relationship between glutathione peroxidase activities, an antioxidant enzyme, and the oxidative status in diabetic rat blood. METHODS Malondialdehyde level and glutathione peroxidase activity were measured by spectrophotometric techniques. RESULTS AND CONCLUSIONS Malondialdehyde content in the diabetic rats group was increased compared to that in...

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

introduction: amnesia or loss of memory is the cardinal hallmark of alzheimer’s disease (ad), a progressive neurodegenerative disorder associated with ageing process. although, ad had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. however, there has been a growing interest in the use of phytomedicines with m...

PURPOSE To evaluate modes of cataractogenesis in the hypertensive state by using different hypertensive animal models, including fructose, cadmium chloride (CdCl2), N ω-nitro-l-arginine methyl ester (l-NAME), and two-kidney, one clip (2K1C) method. METHODS Male Sprague-Dawley albino rats (150-180 g) were divided into different groups, each group containing six animals. Hypertension was induce...

AIMS AND BACKGROUND To compare the antioxidant status of cervical cancer patients with healthy controls and to assess the antioxidant levels before and after radiotherapy or radiochemotherapy. METHODS AND STUDY DESIGN Antioxidant levels (glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde) were measured in 35 patients with cervical cancer and 35 age-matched healthy ...

background the molecular mechanism of hepatitis c-virus (hcv) genome-specific pathogenesis remains unclear. oxidative stress is an important pathophysiological mechanism in chronic hcv infection, but its relation to hcv genotypes has not been thoroughly examined. objectives in the present case-control study, the effect of diverse hcv genotypes on oxidative status changes was investigated. patie...