Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis. Methods: Antinociceptive activity was determined by acetic acid-induced writhing and formalin-induced licking test in mice. Then, molecular docking study was performed to identify compounds havin...

objective(s): nowadays, cox- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. in response to this, medicinal chemists have attempted to synthesize new classes of cox-2 inhibitors.   materials and methods: in this study, three novel analogues of thiazolidin-4-ones derivatives 2a-c were synthe...

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was com...

Acute treatment with the chloroform fraction of Dioclea virgata (Rich.) Amshoff (CFDv) in mice produced decreased ambulation and sedation in the behavioral pharmacological screening. Doses of 125 and 250 mg/kg CFDv decreased latency of sleep onset in the test of sleeping time potentiation. In the open field, animals treated with CFDv reduced ambulation and rearing (250 mg/kg), as well as defeca...

Objective: In this study, it was aimed to investigate the antinociceptive activity potential of Tofisopam and elucidate possible involvement opioid system in effect.Material Method: The efficacy (25 50 mg/kg) evaluated by hot-plate acetic acid-induced writhing tests; while effects drug on motor coordination mice were with Rota-rod tests.Result Discussion: at a dose mg/kg significantly prolonged...

In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and ...