antineutrophil cytoplasmic autoantibodies (anca) were detected in patients with autoimmune and vascular diseases such as wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. indirect immunofluorescence (iif) technique was employed to detect these autoantibodies. by this method, two general patterns of anca were seen: a cytoplasmic (canca) and a perinuclear form ...

et al. Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. polychondritis associated with ulcerative colitis. Serial determinations of antibodies to cartilage and circulating immune complexes by three assays.s granulomatosis: dermatological manifestations in 75 cases with clinicopatho-logic correlat...

Key words: anti-GBM antibodies; Goodpasture's dis-titre of 252 IU. Antineutrophil cytoplasmic antibodies (ANCA) (in house assay), rheumatoid factor, and ease; insulin-dependent diabetes mellitus; simultaneous presentation cryoglobulins were negative. A renal biopsy demonstrated a florid crescentic glomerulonephritis with all glomeruli involved. Immunofluorescence showed strongly positive IgG an...

OBJECTIVE ANCA has come to play an important role in diagnosing vasculitis. In selected populations c-ANCA/PR3-ANCA has a high specificity and sensitivity for vasculitis. In clinical practice, how individuals with c-ANCA/PR3-ANCA but without sufficient evidence of systemic vasculitis should be managed is unclear. We therefore retrospectively assessed the disease panorama and outcome in a consec...

Granulomatosis with polyangiitis (GPA) is a primary vasculitis associated antineutrophil cytoplasmic antibodies, characterized by necrotizing predominant involvement of small vessels various localizations and granulomatous inflammation multiple clinical manifestations. GPA remains one the most severe systemic unfavorable prognosis. When analyzing course disease, there are two variants GPA, loca...

and dysmorphic red blood cell casts. A quantitative serum pregnancy test was positive. Bronchoalveolar lavage retrieved blood-tinged fluid, numerous red blood cells and hemosiderin-laden macrophages but few neutrophils. Microbiology studies for bacteria, mycobacteria and fungi in the bronchoalveolar lavage fluid were negative. Perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) with spec...