A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures o...

This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistam...

Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

OBJECTIVE Pediatric cough and cold medications are widely marketed in the United States, but the precise patterns of use among children are not known. Such information is especially important given recent reports suggesting that these medications are responsible for previously underappreciated serious adverse events and deaths among children. We sought to describe the prevalence and patterns of...

BACKGROUND Current national efforts provide an opportunity to integrate performance measures into clinical practice and improve outcomes for children. OBJECTIVE The goal of this study was to explore issues in developing and testing measures of care for children with otitis media with effusion (OME). METHODS We assessed compliance with diagnostic, evaluation, and treatment measures for OME a...

Objective: To compare the efficacy of autologous serum with Antihistamine therapy in treating chronic urticaria.
 Study Design: Quasi-experimental study.
 Place and Duration Study: Dermatology Department, Pak Emirate Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.
 Methodology: One hundred four patients urticaria (≥3 times/ week for ≥6 weeks) ages ranging 16 70...

Introduction. Acute infectious rhinitis refers to the frequent causes of discharge therapy with nasal decongestants. The aim analyze clinical features unloading acute 0.1 % xylometazoline according materials research centers Novosibirsk and Yekaterinburg. Materials methods. In Yekaterinburg, patients were observed. Intranasal in study groups (group 1) comparison 2) was carried out spray for 7 d...

BACKGROUND Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not. OBJECTIVE To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment. METH...