Skin is a unique target for vaccination. Targeting keratinocytes to produce proinflammatory mediators improve immunity rational approach vaccine design. Keratinocytes genetically engineered overexpress the stress response related transcription factor x-box binding protein 1 (XBP1) increased production of and co-delivered antigen. Keratinocyte-specific overexpression XBP1 through cutaneous genet...

Antigen presentation via major histocompatibility complex (MHC) class I and II receptors plays a fundamental role in T cell-mediated adaptive immunity. A dysregulation of this fine-tuned recognition might result the development autoimmune diseases such as inflammatory bowel that are characterized by chronic relapsing inflammation intestinal tract damaged epithelial barrier. While MHCII usually ...

computational tools are reliable alternatives to laborious work in chimeric protein design. in this study, a chimeric antigen was designed using computational techniques for simultaneous detection of anti-htlv-i and anti-hbv in infected sera. databases were searched for amino acid sequences of hbv/hlv-i diagnostic antigens. the immunodominant fragments were selected based on propensity scales. ...

Abstract Successful initiation of the B-cell receptor (BCR) signaling, and subsequent antigen-encounter in germinal centers are both marked by sharp increases CD25 surface-expression. Likewise, oncogenic signaling leukemia (B-ALL) lymphoma induces CD25-surface expression. While is known as an IL2-receptor chain on T- NK-cells, significance its expression B-cells was unclear. We discovered that,...

considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofcd44 and cd45rb expression in cd8+ murine t cells with prior exposure to antigen or staphylococcal enterotoxin b ( seb ). following in vivo priming with two purified protein derivatives (one from a virulent who strain and the other from an avirulent strain), t cell...

Resistance to immunotherapy is due in some instances the acquired stealth mechanisms of tumor cells that lose expression MHC class I antigen–presenting molecules or downregulate their antigen–presentation pathways. Most dramatically, biallelic ?2-microglobulin (B2M) loss leads complete and invisibility CD8 + T cells. antigen presentation are potently upregulated by interferon-? (IFN?) a manner ...

Abstract High-grade serous ovarian cancers (HGSOC) represent the most common subtype of malignancies. Due to frequency late-stage diagnosis and high rates recurrence following standard care treatments, novel therapies are needed promote durable responses. We investigated anti-tumor activity CD3 T cell engaging bispecific antibodies (TCBs) directed against PAX8 lineage-driven HGSOC tumor antigen...