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BACKGROUND Studies with healthy volunteers have demonstrated that antidepressants can improve immunoregulatory activity and thus they may have a potential to positively impact the disease course in inflammatory bowel disease (IBD), a chronic and incurable condition. However, patients' views on the role of antidepressants in the management of their IBD are unknown. Thus, this study aimed to expl...

This paper is a brief review which deals with research findings, clinical issues, and strategies in the pharmacotherapy of clinical depression. The author introduces antidepressants which are currently available in the United States. They include heterocyclic antidepressants (tricyclic antidepressants and second-generation antidepressants), monoamine oxidase inhibitors, lithium, carbamazepine, ...

Die Starke-Perfekte-Graphen-Vermutung, ein seit 40 Jahren offenes und herausragendes Problem der Graphentheorie, scheint gelöst zu sein. Nach über zwei Jahren intensiver Forschung kündigten Ende Mai 2002 Maria Chudnovsky (Princeton), Neil Robertson (Ohio State), Paul Seymour (Princeton) und Robin Thomas (Georgia Tech) einen Beweis der Vermutung an. Das noch unveröffentlichte Manuskript soll ca....

Antidepressants are drugs with a direct action on the brain's biochemistry through their interaction neurotransmitters, such as dopamine, norepinephrine, and serotonin. The increasing worldwide contamination from these may be witnessed presence in urban water cycle. Furthermore, occurrence has been detected non-urban water, rivers oceans. Some endemic aquatic animals, certain fish mollusks, hav...

Most inequality research on the relationship between inequality and mental health has focused on cross-country variation. Findings from within-country data are mixed. We examined whether changes in municipal Gini index or in the share of people living in relative poverty were linked to changes in the use of antidepressants in several Finnish municipalities between 1995 and 2010. We found that m...

BACKGROUND By blocking the serotonin transporter system antidepressants can, in theory, result in bleedings. However, we do not yet know how great the risk of bleeding is and what the clinical implications are. AIM To assess how great the risk of bleeding is and what the clinical implications are. METHOD Using keywords 'antidepressants' and 'bleeding' we searched the relevant literature up ...

BACKGROUND Treatment of negative symptoms in chronic schizophrenia continues to be a major clinical issue. AIMS To analyse the efficacy of add-on antidepressants for the treatment of negative symptoms of chronic schizophrenia. METHOD Systematic review and meta-analysis of randomised controlled trials comparing the effect of antidepressants and placebo on the negative symptoms of chronic sch...

Empirical evidence regarding the association between antidepressants and valvular heart disease (VHD) is scarce.Using Taiwan's National Health Insurance Research database, this nested case-control study assessed the association between antidepressants and VHD in a Chinese population.Among a cohort of patients who used at least 3 prescription antidepressants, 874 cases with VHD and 3496 matched ...