A wide diversity of animal models has been used to examine antidepressant activity. These range from relatively simple models sensitive to acute treatment, to highly sophisticated models that reputedly model some aspect of depressive illness and which yield a positive response to prolonged, chronic, drug treatment. In recent years antidepressant drug research has focused on the search for antid...

Background & Aim: Depression is a heterogeneous mood disorder affecting both people in developing and developed countries. The drugs used in its management are associated with adverse effects and delayed response which compromise their therapeutic benefits. This makes it worthwhile to look for antidepressants plants with proven advantage and favourable benefit-...

The aim of this study has been to investigate the effects of vasopressin and oxytocin on antidepressive and memory improving effects of venlafaxine. Male Wistar rats weighing 180-200 g were used in the study. Venlafaxine (20 mg/kg) was administered po 30 min before the test once, and for 7 and 14 days in the chronic experiments. Oxytocin (1 microg/kg) ip and vasopressin (1 microg/kg) sc were ad...

Aim of the study: Averrhoa bilimbi is used to treat a variety illnesses, including those that affect central nervous system. In this study, albino rats were given methanolic extract leaves (MEAB) investigate its effects using behavioral assays are sensitive antidepressants with clinical efficacy. Methodology: When mice subjected Tail suspension test (TST) and Forced swim (FST), (125,250, 500mg/...

Mirtazapine {1,2,3,4,10,14b-hexa-hydro-2-meth-ylpyrazino [2,1a] pyrido [2,3-c]benzazepin} is a tetracyclic compound with antidepressant activity in human [1]. Mirtazapine has a unique mechanism of action, different from that of the classical tricyclic antidepressants, the serotonin selective reuptake inhibitors and monoamine oxidase inhibitors, and could be described as a noradrenergic and spec...

Background: Depression is one of the most common causes disabilities and poor quality life worldwide. One-fifth patients fail to respond antidepressant therapy. Hence, adjunct therapy urgently needed. Aim: This study aims compare effectiveness repetitive transcranial magnetic stimulation (rTMS) aerobic exercise as on activity daily living in depressed patients. Material Methods: A randomized-co...

OBJECTIVES Hypericum spp. (H.) has been used in traditional medicine for their sedative effect for many years. In spite of many works on this genus, little is known about H. scabrum. In this work antidepressant and its protective effect against hypoxia-induced lethality were evaluated. MATERIALS AND METHODS Antidepressant and its protective effects against hypoxia-induced lethality were evalu...

A new series of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives were synthesized and evaluated for their anticonvulsive activity in a pentylenetetrazole (PTZ)-evoked convulsion model and antidepressant activity in the forced swimming test (FST) model. Eleven synthesized compounds were found to be protective against PTZ-induced seizure and showed the anticonvulsant activity. In addition,...

The present study was done to evaluate the effect of aqueous extract of B. diffusa on depression in mice using behavioral models such as tail suspension test (TST) and forced swim test (FST). The extract (50, 100 and 200 mg/kg, po) was administered for 14 successive days to Swiss young albino mice. On 14th day, 60 min after administration, mice were subjected to TST and FST. The administration ...

Antidepressant activity of crocin, saffron main component, has been established before. Based on previous study, it is suggested that elevation in the levels of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the r...