نتایج جستجو برای: antibody engineering
تعداد نتایج: 427346 فیلتر نتایج به سال:
Therapeutic monoclonal antibodies targeting G-protein-coupled receptors (GPCRs) are desirable for intervention in a wide range of disease processes. The discovery of such antibodies is challenging due to a lack of stability of many GPCRs as purified proteins. We describe here the generation of Fpro0165, a human anti-formyl peptide receptor 1 (FPR1) antibody generated by variable domain engineer...
Antibodies are an essential biotechnological tool being a part of immunodiagnostics, therapeutics and life science research instruments. Due to the advances of molecular biology methods, it became possible to manipulate structure and properties of antigen-binding domains of antibodies (1). This led to the creation of a variety of small-sized, single-domain, bi-specific, conjugated antibodies, a...
Immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising targets for cancer immunotherapies. To optimize the agonism of therapeutic antibodies to these receptors, Fc engineering of antibodies was applied to facilitate the clustering of cell surface TNFRs to activate downstream signaling pathways. One engineering strategy is to iden...
Since the development of antibody-production techniques, a number of immunoglobulins have been developed on a large scale using conventional methods. Hybridoma technology opened a new horizon in the production of antibodies against target antigens of infectious pathogens, malignant diseases including autoimmune disorders, and numerous potent toxins. However, these clinical humanized or chimeric...
Most hormones and proteins as well as many drugs are currently determined by immunoassay. Clinicians generally trust that the results they get are correct, but this is not always the case. Several recent studies have described examples of nonspecific interferences producing misleading results. Many of the interfering factors have been known for decades and thoroughly discussed in this and other...
(2003). Characterization of antibody-antigen interactions by fluo-rescence spectroscopy. In: Lo, Benny and Chen, Yu Wai eds. Antibody engineering: methods and protocols.
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