Hereditary deficiencies of early complement components have usually been associated with the development of rheumatic diseases like systemic lupus erythematosus (SLE), while terminal component deficiency is well known to predispose to recurrent neisserial infection. In contrast, only recently have patients been reported with rheumatic disease and hereditary deficiency of a terminal component. T...

The review of non-cystic fibrosis bronchiectasis by Smith elegantly highlights the lack of evidence available in some areas. In particular, approach to immunological testing is varied. Table 2 on page 134 in this review describes the diagnostic features required for immunodeficiency (including immunoglobulin G [IgG] subclass 2 deficiency amongst other IgG subclass deficiencies). However, IgG su...

AIMS To review our experience of anti-D immunoglobulin for immune thrombocytopenia (ITP) in patients with primary antibody deficiency. METHODS/PATIENTS A retrospective case notes review of four Rhesus positive patients with ITP and primary antibody deficiency, treated with anti-D. Patients were refractory to steroids and high dose intravenous immunoglobulin (IVIG). Two patients were previousl...

iron deficiency can cause cognitive and functional learning disorders in children. some studies have reported a relationship between low serum ferritin levels in patients with anemia and helicobacter pylori (h. pylori) infection. therefore, we aimed to determine the relationship between these two common diseases. this descriptive analytical cross-sectional study was performed to assess serum fe...

The assessment of the humoral immune response is a critical component in the evaluation of patients suspected of having a primary immune deficiency disease (PIDD).1 In fact, more than 50% of the patients with immune deficiency have some impairment in the ability to make specific antibodies and/or have a quantitative deficiency of antibodies. Although there are a number of laboratory tools that ...

The primary antibody deficiency syndromes are characterised by recurrent respiratory tract infections and the inability to produce effective immunoglobulin (Ig) responses. The best-known primary antibody deficiencies are common variable immunodeficiency (CVID), X-linked agammaglobulinaemia (XLA), immunoglobulin G (IgG) subclass deficiency, and selective antibody deficiency with normal immunoglo...

This Review summarises current knowledge on the pulmonary manifestations of primary antibody deficiency (PAD) syndromes in adults. We describe the major PAD syndromes, with a particular focus on common variable immunodeficiency (CVID). Respiratory infection is a common presenting feature of PAD syndromes. Respiratory complications are frequent and responsible for much of the morbidity and morta...

OBJECTIVE The aim of this study was to evaluate pulmonary complications in patients with primary antibody deficiency (X-linked agammaglobulinaemia [XLA] and common variable immunodeficiency [CVID]). METHODS Thirty patients over six years of age regularly followed in a reference out-patient clinic on primary immunodeficiency were studied. All of them have been treated with intravenous immunogl...