Clewe, O. 2016. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 222. 70 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9718-7. With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent n...

Mycobacterium tuberculosis has an on-going impact on global public health and new therapeutics to treat tuberculosis are urgently required. The emergence of drug resistant tuberculosis poses a serious threat to the control of this pathogen, and the development of drugs that are active against the resistant strains is vital. A medium-throughput assay using the Alamar Blue reagent was set-up to i...

Background: Four oral anti-tuberculosis drugs are conceived to be the most effective ones eradicate Mycobacterium tuberculosis bacteria and obviate resistant organisms. However, patients' adherence medication discrepancies obstacles achieving goal. This study aimed define used in hospitals detect continuity of treatment.Design Methods: retrospective cross-sectional was based on medical records ...

It is believed that tuberculosis has been killing human beings for over 4000 years. Several reports exist of ancient Egyptian mummies having signs of tubercular decay in their bodies. After the discovery of powerful anti-TB drugs such as streptomycin, isoniazid and rifampin during 1940-70s, it was thought that TB would be gone from the face of the earth, but tuberculosis still remains one of th...

Indonesia was the second world's highest TB case in 2021. Tuberculosis therapy that takes a long time can cause patients to drop out of treatment. Hospitals conduct quality evaluations regularly and improve health service personnel realize excellent services. This literature review aims determine effect tuberculosis services on patient compliance with anti-tuberculosis drugs. written using syst...

Tuberculosis (TB) is a disease which can affect various organs, including human's genital organs such as the endometrium. Tuberculosis endometritis can cause clinical symptoms of secondary amenorrhea and infertility. Infertility in genital TB caused by the involvement of the endometrium. The case presentation is 33-year-old woman from dr. Saiful Anwar Public Hospital to consult that she has not...

It is believed that tuberculosis has been killing human beings for over 4000 years. Several reports exist of ancient Egyptian mummies having signs of tubercular decay in their bodies. After the discovery of powerful anti-TB drugs such as streptomycin, isoniazid and rifampin during 1940-70s, it was thought that TB would be gone from the face of the earth, but tuberculosis still remains one of th...

tuberculosis of the foot is an uncommon entity and the reported incidence is 0.1% to 0.3%. the isolated tuberculosis of talonavicular joint is exceptionally rare. in tuberculosis of the foot and ankle, the presentation is usually nonspecific. the diagnosis of tuberculosis affecting foot is difficult, especially when it is isolated. in doubtful cases, diagnosis should be confirmed by histopathol...

The emergence of drug-resistant Tuberculosis has become a global health problem. Herbal drugs promise other potential options for treatment. This study aimed to investigate the anti-mycobacterial activity three plants: Piper longum, Cressa cretica and Calotropis gigantea. methanolic extract these plants was tested against Mycobacterium tuberculosis H37Rv using BACTEC MGIT-960 Automated system, ...

rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. this study was undertaken to examine the therapeutic potency of tindurin in experimental rheumatoid arthritis. collagen-induced arthritis (cia) was induced by intradermally immunization of lewis rats at the base of th...