Seizure is an important complication following ischemic or hemorrhagic stroke in older adults. Post-stroke seizure can be classified as early late according to the onset time after stroke. There a 71% risk for further seizures unprovoked poststroke seizure, which referred epilepsy. Common factors developing epilepsy include severity, cortical involvement, and seizure. The use of anti-seizure me...

This paper proposes a class of algorithms for analyzing event count time series, based on state space modeling and Kalman filtering. While the dynamics model is kept Gaussian linear, nonlinear observation function chosen. In order to estimate states, an iterated extended filter employed. Positive definiteness covariance matrices preserved by square-root filtering approach, singular value decomp...

Neonatal period is the most vulnerable time for the occurrence of seizures, and neonatal seizures often pose a clinical challenge both for their acute management and frequency of associated long-term co-morbidities. Etiologies of neonatal seizures are known to play a primary role in the anti-epileptic drug responsiveness and the long-term sequelae. Recent studies have suggested that burden of a...

Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model of temporal lobe epilepsy in rats using both Agilent and Codelink microarray platforms to characte...

Abstract Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury (TBI). Methods A total 95 TBI were recruited from 2017 to 2020. They randomized into three groups: (LEV) group ( n = 30) receiving LEV treatment (500 mg, bid, po); 32) sodium mg/d, once daily, control 33) no anti-seizure medication. g...

Anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis, recently recognized as a form of paraneoplastic encephalitis, is characterized by a prodromal phase of unspecific illness with fever that resembles a viral disease. The prodromal phase is followed by seizures, disturbed consciousness, psychiatric features, prominent abnormal movements, and autonomic imbalance. Here, we report a case ...

BACKGROUND Anti N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune mediated disorder. CASE CHARACTERISTICS A previously healthy 14-year-old girl presenting with generalized tonic clonic seizures and altered behavior. OBSERVATION In view of refractory seizures, hallucinations, psychobehavioral and catalepsy like symptoms, and CSF showing lymphocytic pleocytosis, possibility of au...

objective to evaluate the efficacy and common side effects of intermittent clonazepam in febrile  seizures. materials & methods this study was an experimental trial designed to determine the efficacy of intermittent clonazepam in febrile seizures .thirty patients with an age range of 6 months to 5 years (60% male, 40% female) were studied. children with a history of psychomotor delay, abnormal ...

Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1) protein is known to contribute significantly to the generation of seizures. Here, we investigated the therapeutic potential of an anti-HMGB1 monoclonal antibody (mAb) in epilepsy. anti-HMGB1 mAb attenuated both acute seizure models (maximal electroshock seizure, pentylenetetrazole-induced and kindling-in...