Aim: The present study was performed to evaluate the anti-quorum sensing (QS) potential of traditional medicinal herb Saracaasoca (family Caesalpiniaceae) stem bark extract against Chromobacterium violaceum and Pseudomonas aeruginosa PA01.
 Study Design: First, test sample (bark extract) screened for anti-QS activity. Then systematic in-vitro biochemical tests were effect on QS mediated vi...

ABSTRACT Acinetobacter baumannii possesses a single divergent luxR / luxRI -type quorum-sensing (QS) locus named abaR abaI . This also contains third gene located between and , which we term abaM that codes for an uncharacterized member of the RsaM protein family known to regulate N -acylhomoserine lactone (AHL)-dependent QS in other beta- gammaproteobacteria. Here, show disruption via T26 inse...

The emergence of bacteria resistant to conventional antibiotics and the inability these treat bacterial biofilm-induced infections cause millions deaths every year. This situation has prompted scientists develop alternative strategies combat infectious diseases. Among these, researches on phytochemicals reduce virulence in Pseudomonas aeruginosa have gained momentum recent years. main reasons b...

Quorum sensing (QS), acts as one of the gene regulatory systems that allow bacteria to regulate their physiological activities by sensing the population density with synchronization of the signaling molecules that they produce. Here, we report a marine isolate, namely strain T47, and its unique AHL profile. Strain T47 was identified using 16S rRNA sequence analysis confirming that it is a membe...

Quorum sensing (QS) describes the exchange of chemical signals in bacterial populations to adjust the bacterial phenotypes according to the density of bacterial cells. This serves to express phenotypes that are advantageous for the group and ensure bacterial survival. To do so, bacterial cells synthesize autoinducer (AI) molecules, release them to the environment, and take them up. Thereby, the...

Diabetic foot ulcers are recognized to be a severe complication of diabetes, increasing the risk amputation and death. The bacterial infection with virulent resistant bacteria as Proteus mirabilis greatly worsens wound may not treated conventional therapeutics. Developing new approaches target virulence can helpful conquer such infections. In current work, we evaluated anti-virulence activities...

Azadirachta indica (Neem ) is an important medicinal plant with proven strong antiseptic, antiviral, antifungal and antibacterial properties. The study here presents the QS (Quorum Sensing) inhibitory potential of biogenic Silver nanopaticles (AgNPs) from leaf extracts. nanoparticles were synthesized using aqueous extract leaves silver nitrate solution. size, crystal structure, elemental compos...

UNLABELLED In bacteria, RNAs regulate gene expression and function via several mechanisms. An RNA may pair with complementary sequences in a target RNA to impact transcription, translation, or degradation of the target. Control of conjugation of pCF10, a pheromone response plasmid of Enterococcus faecalis, is a well-characterized system that serves as a model for the regulation of gene expressi...

Pseudomonas aeruginosa is an opportunistic pathogen, having complicated quorum sensing (QS) system utilizing multiple signals and receptors to coordinate virulence pathogenicity. N-acyl-homoserine-lactones (AHLs) are the most common autoinducers responsible for regulation of QS-mediated gene expression. There four QS systems in P. among which LasI/R RhlI/R regulated by 3-oxo-C12-HSL C4-HSL resp...

This study reported the efficacy of the metabolites of Plectosphaerella cucumerina, one phyllosphere fungus from Orychophragmus violaceus, against Pseudomonas aeruginosa quorum sensing (QS) and QS-regulated biofilms. The minimum inhibitory concentration (MIC) of the ethyl acetate (EtOAc) extract from P. cucumerina against P. aeruginosa PAO1 was 1.25 mg mL-1. At sub-MIC concentrations, P. cucume...