a 53-year-old male was referred to our department for refractory primary hypertension. despite high doses of 6 anti-hypertensive drugs, ambulatory monitoring of blood pressure (bp) revealed a mean bp of 160/90 mmhg. under local anaesthesia, renal denervation with radiofrequency was performed supported by high-resolution 3d angiography, which helped confirm the position of the applications in a ...

PURPOSE To evaluate physicians' prescribing of anti-hypertensive drug combinations in a tertiary care setting in southwestern Nigeria, determine the degree of usage of Angiotensin Converting Enzyme (ACE) inhibitor-based combinations and identify specific points of intervention to improve outcomes of anti-hypertensive combination therapy. METHODS A cross-sectional retrospective drug use review...

Recent studies indicate that chronic ouabain treatment leads to hypertension and hypertensive vascular remodeling. Grape seed proanthocyanidin extract (GSPE) has been reported to be effective in treating arteriosclerosis, while little is known about its effect on systolic blood pressure and vascular remodeling. In this study, the effects of GSPE o...

High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using...

OBJECTIVE To assess prescriber adherence to standard anti-hypertensive treatment guidelines in South Africa, determine if supply data are useful indicators of drug use, and assess the cost implications of not complying with the guidelines. METHODS We undertook two studies: an analysis of records of the anti-hypertensive drugs supplied to all 54 public-sector hospitals with a hypertension clin...

apium graveolence has an small brown olyptical seed with pharmacological activity. to evaluate it's application in treatment of hypertension, 37 hypertensive patients (20 female, 17 male) with the age range of 45-65 were given 6 grams of powder of apium graveolence seed and then the blood pressures before and after the remedy were compared. before treatment, the mean systolic blood pressur...