An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 microg/mL against Staphylococcus aureus.

To our knowledge, previous population-based surveys have not assessed misconceptions about antibacterial drug use over time. We documented a 26.3% decline in a key misconception in California women in 2003 compared to 2000; declines varied significantly by education level. Educational campaigns specifically designed to influence important subpopulations are needed.

In studies of the interactions of antibacterial agents, it became important to try to elicit bacterial resistance to antibiotics in the experimental animal. Since this proved to be unexpectedly difficult, attention was directed to the process by which bacteria acquire resistance during exposure in vivo. The present paper is concerned with the incidence of streptomycin resistance in strains of s...

Drug resistance in fecal bacteria was high in Wayampis Amerindians who did not take antibacterial agents and were not hospitalized for 1 year. In the Wayampis Amerindians, an isolated traditional community in French Guyana, antibacterial use was 0.64 treatments per person per year. Hospitalization rate was 6.1% per year. Antibacterial drug-resistant bacteria can spread in persons who are not ta...

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhi...

Background and Objective: The endophytes are the fungi or bacteria that live within a plant in a symbiotic relationship. This study aimed to investigate the effect of isolated bacterial endophytes from Allium jesdianum on some bacterial pathogens such as Staphylococcus aureus, Escherichia coli as well as pathogenic fungi, including Trichophyton mentagrophytes and Candida albicans. Materials an...

context to provide an updated review of published literature on the anti-oxidant, anti-bacterial and anti-inflammatory properties of honey. evidence acquisition cinahl, biomed central, cochrane library, medline and embase data bases and reference lists were used to find randomized controlled trials and review articles. randomized controlled trials using honey with a comparator were reviewed, al...

Background: Microbial infections and the resistance to antibacterial drugs are on the rise, and scientists are in search of the safest and most effective approach to overcome them. Medicinal plants are potentially effective against many microorganisms. Therefore, this study was planned to examine the antibacterial properties and cytotoxicity of the extracts of Allium sativum and Myrtus communis...

Fluoroquinolones are one of the most promising and vigorously pursued areas of contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They have a relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and a relatively low in...