Tryptophan and its intermediate metabolites in the synovial fluid were studied in order to know a specificity of the tryptophan metabolism in rheumatoid arthritis and osteoarthritis. A metabolic map was made, and the pathways of tryptophan breakdown in both diseases were compared. It was found that tryp tophan in rheumatoid arthritis was metabolized mainly to anthranilic acid through kynurenine...

Insertion of an anthranilic acid in an amyloidogenic peptide sequence generates a novel conformationally restricted α/β-hybrid peptide that inhibits amyloid formation of Aβ(1-40) and disrupts preformed fibrillar aggregates in vitro. Such β-sheet breaker hybrid peptides (BSBHps) may be useful for designing novel physiologically important compounds relevant to diverse amyloidoses and for studying...

Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4bromophenyl)-6-bromo-3(H)-quinazolin-4-one ligand called HAMQ (HL11) was studied. To prepare this ligand anthranilic acid was converted into 5-bromo–N-Chloroacetyl anthranilic acid then into 2-[(8-hydroxyquinolinyl) -5-aminomethyl] -3-(4-bromophenyl) 6-Bromo3(H)-quinazolin-4-one. This compound was finally condensed wi...

Polar mutations in trpA, the first structural gene of the tryptophan operon of Salmonella typhimurium, have an uncoordinate effect on the expression of the distal genes, with trpB, the second gene, being more drastically affected than the last three. A number of these polar mutant strains grow very poorly on anthranilic acid-supplemented minimal medium. By selecting for more rapid growth in the...