Our previous studies have shown that riboflavin has activity against Plasmodium falciparum asexual-stage parasites in vitro. In the present study we examine the gametocytocidal activity of riboflavin and the interaction of riboflavin with some commonly used antimalarial drugs against the asexual forms of P. falciparum in vitro. The addition of riboflavin to P. falciparum cultures killed gametoc...

This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB+TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER+TIG showed lower survi...

Abstract Background Lentil ( Lens culinaris Medik.) is one of the major pulse crops in world. The present study aimed to evaluate effect Trichoderma isolates control charcoal rot disease caused by Macrophomina pseudophaseolina recently reported on lentil plants. Results In this study, antagonistic effects seven spp. isolated from rhizosphere were evaluated vitro against M1. All significantly re...

OBJECTIVES The in vitro and in vivo efficacy and drug-drug interactions of the novel semi-synthetic endoperoxide artemisone with standard antimalarials were investigated in order to provide the basis for the selection of the best partner drug. METHODS Antimalarial activity and drug interactions were evaluated in vitro against Plasmodium falciparum by the incorporation of [(3)H]hypoxanthine. I...

Ink disease is a devastating of chestnut (Castanea sativa) worldwide, caused by Phytophthora species. The only management measures this are chemical and agronomic interventions. This work focuses on the evaluation in vitro antagonistic capacity 20 isolates Trichoderma spp. selected diseased orchard Tuscan Apennines (San Godenzo, Italy) for biocontrol xcambivora. Each isolate was tested to inves...