BACKGROUND Worldwide cervical cancer remains a leading cause of mortality from gynecologic malignancies. The link between cervical cancer and persistent infection with HPV has been established. At a molecular level little is known about the transition from the precancerous state to invasive cancer. To elucidate this process, cervical biopsies from human specimens were obtained from precancerous...

Background: The prevalence of lung cancer has shown an increase over the last few years which cause both health and economic burden. biopsy is gold standard tool for disease diagnosis, but it usually not accepted by patients due to its invasive nature. use non-invasive biomarkers now attaining a great interest in diagnosis. Aim work: Assess role Annexin A1 bronchoalveolar lavage serum early dia...

Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, we show that ligand-receptor-mediated signaling promotes reactive oxygen species-dependent protein carbonylation. Treatment of pulmonary artery smooth muscle cells with endothelin-1 increased protein carbonyls. Carbonylation of the majority of ...