The paper gives a brief introduction to canine oncology, including its comparative aspects as basis for recording tumours in the animal kingdom. In an abbreviated presentation of the Norwegian Canine Cancer Project for the years 1990-1998, the data (n=14,401) were divided into age groups, each of two years, into different categories of tumours, and into age and gender. As expected, cutaneous hi...

In Indian rhinoceros, extensive leiomyoma, a benign smooth muscle tumour, was sporadically diagnosed post mortem and commonly thought of as contributing factor for reduced fecundity of this species in captivity. However, to date, the prevalence of reproductive tract tumours and their relevance for fecundity are unknown. Our analysis of the international studbook now reveals that females cease r...

Jel ínek F. : Spontaneous Tumours in Guinea Pigs. Acta Vet. Brno 2003, 72: 221-228. The aim of the study is to describe spontaneous tumours in guinea pigs. Twenty neoplasias from 19 guinea pigs were examined histologically. In 15 cases biopsy samples were examined, samples from four animals were collected during autopsy. Except for one, all animals were kept as pets. Skin tumours were diagnosed...

the rectum villous tumour is an uncommon pathology in paediatrics, it represent 1% of all the children's malign tumours. an eleven-year-old girl present a rectal adenocarcinoma developed from a villous tumour. the aim of this study is to assess , an overview of litterature, the frequency of rectum villous tumours; to specify the value of the clinical examination , of the radiologic finding in t...

The majority of liver tumours are inoperable and an alternative treatment to surgical resection is urgently needed. Electrolysis has been investigated in a rat model and the procedure is safe, with accurate and predictable effects. The necrosis produced has also been shown to cause destruction of tumour deposits in the rat liver. A similar evaluation in a large animal model was necessary before...

The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortality are the direct results of metastatic cancers, the increasing use of clinically-relevant metasta...

In the past decade appreciable evidence has accumulated from clinical observation to support the concept that host factors may influence the development and progression of lluman cancer. While some tumours grow without apparent restraint, others such as carcinoma of the breast and prostate may be inhibited by appropriate endocrine modification (Huggins 1967). Further evidence suggestive of the ...

Xenografts from eight human bronchial carcinomas have been established in CBA/Lac mice rendered immunodeficient by neonatal thymectomy followed three weeks later by whole body irradiation (7.35 Gy (735 rads)) after a priming dose of cytosine arabinoside. Growth rates of individual tumour lines remain constant and the histological and chromosomal characteristics of the original tumour are mainta...

Melanoma is a malignant tumour that originates from melanocytes. It has been reported in human beings as well many domesticated animal species (Reddy et al., 1998), and wild terrestrial marine animals. Melanomas are the most commonly diagnosed tumours oral cavity of canines (Goldschmidt, 1985; Faramade 2017). Gingiva common site for canine melanoma (OMM) but other parts like palatine, labile or...

Recent reports have called into question the reproducibility, validity and translatability of the preclinical animal studies due to limitations in their experimental design and statistical analysis. To this end, we implemented a matching-based modelling approach for optimal intervention group allocation, randomization and power calculations, which takes full account of the complex animal charac...