Lokenga Badinga and Charles R. Staples Department of Animal Sciences University of Florida Gainesville, Florida Definition and Sources of Conjugated Linoleic Acid Conjugated linoleic acid (CLA) is a collective term describing a mixture of positional and geometrical isomers of linoleic acid (LA, C18:2) involving a double bond at positions 8 and 10, 9 and 11, 10 and 12 or 11 and 13 (Eulitz et al....

Arginine and Conjugated Linoleic Acid Reduce Fat Mass in Rats. (May 2008) Jennifer Lynn Nall, B.S., Texas A&M University Chair of Advisory Committee: Dr. Stephen B. Smith This experiment tested the hypothesis that the combination of dietary conjugated linoleic acid (CLA) plus arginine will decrease fat accumulation and increase muscle mass. Twenty-four male Sprague Dawley rats were assigned to ...

BACKGROUND We recently showed that trans-10,cis-12 (t10,c12) conjugated linoleic acid (CLA) causes insulin resistance in obese men. However, metabolic effects of the c9,t11 CLA isomer are still unknown in obese men. Because c9,t11 CLA is the predominant CLA isomer in foods and is included in dietary weight-loss products, it is important to conduct randomized controlled studies that use c9,t11 C...

Background Caffeine, conjugated linoleic acid (CLA), green tea and branched chain amino acids (BCAA) have shown to individually improve body composition in overweight and obese men and women. The purpose of this study was to investigate the effects of a multi-ingredient dietary supplement containing caffeine, CLA, green tea, and BCAA on body composition and abdominal fat mass in overweight and ...

BACKGROUND Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. OBJECTIVE We therefore sought to directly compare weight loss by 10,12 CLA versus caloric restriction (CR, 15-25%), an acceptable healthy method of weight loss, to determine how 10,12 CLA-medi...

The driving force behind most conjugated linoleic acid (CLA) research in swine has been related to potential improvements in animal production. Early work that used rodent models indicated that feeding CLA could potentially reduce body fat, increase lean content, increase growth rate, and improve feed conversion efficiency. Producer-backed funding organizations were, therefore, receptive to pro...

In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epidid...

OBJECTIVE Conjugated linoleic acid (CLA) has several benefits, including body fat reduction, as proved in animals. However, the results of CLA-induced body composition alterations in humans are inconsistent, and no related data are available for Chinese populations. This study aimed to determine whether CLA affects body weight (BW) loss and body composition of overweight and obese Chinese subje...

Treatment of laboratory animals with a 50:50 mixture of c9,t11 and t10,c12 conjugated linoleic acid (CLA) results in fat loss and, to a smaller degree, fat-free mass (FFM) gain. In a previous meta-analysis, we found that CLA produced a fat loss, but that humans were not as responsive as mice. We performed a similar meta-analysis in the same 18 studies to test whether CLA increased FFM. Only pla...

Conjugated linoleic acid (CLA) reduces body fat reserves, and reduces atherogenesis and type II diabetes in animal experiments. It has been reported that CLA have isomeric-specificity, such as c9, t11 CLA with anticancer activity. The antiproliferative effects of two isomers of CLA (c9, t11-CLA, t9, t11-CLA) and their mixture on the human colon adenocarcinoma cell line Caco-2 were investigated ...