Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein (P-gp) and CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of Rutaceae and Umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from...

PURPOSE Two plant essential oils (EOs), including those from Heracleum transcaucasicum and Heracleum anisactiss (Umbeliferae) were studied to detect the chemical constituents and evaluated for their antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. METHODS The EOs of H. transcaucasicum and H.anisactis (Apiacae) wer...

Furocoumarin-induced DNA damage, monoadducts, and cross-links were measured in normal human, xeroderma pigmentosum, and Panconi's anemia cells after exposure to near-UV (356 nm). At similar concentrations and near-UV doses, photoad dition by 8-methoxypsoralen was twice that by angelicin and the substitution of bromodeoxyuridine for thymidine in one strand of DNA did not alter the binding. The r...

Many exotic plant invaders pose a serious threat to native communities, but little is known about the dynamics of their impacts over time. In this study, we explored the impact of an invasive plant Heracleum mantegazzianum (giant hogweed) at 24 grassland sites invaded for different periods of time (from 11 to 48 years). Native species' richness and productivity were initially reduced by hogweed...

Diversification of cytochrome P450 monooxygenases (P450s) is thought to result from antagonistic interactions between plants and their herbivorous enemies. However, little direct evidence demonstrates the relationship between selection by plant toxins and adaptive changes in herbivore P450s. Here we show that the furanocoumarin-metabolic activity of CYP6B proteins in two species of swallowtail ...

Furanocoumarin derivatives, known as components of grapefruit juice, showing inhibitory effects against P-glycoprotein (P-gp) in the intestine are also contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of byakangelicol and rivulobirin A, known as furanocoumarins showing P-...

background: plant extracts and oils may act as alternatives to conventional pesticides for malaria vector control. the aim of this study was to evaluate the larvicidal activity of essential oils of three plants of apiaceae family against anophe­les stephensi , the main malaria vector in iran. methods: essential oils from heracleum persicum , foeniculum vulgare and coriandrum sativum seeds were ...

One hundred methanol plant extracts were screened for antibiotic activity against Mycobacterium tuberculosis and Mycobacterium avium. Nineteen extracts exhibited some activity against M. tuberculosis and 16 extracts showed some activity against M. avium. Thirteen of these 19 active extracts were traditionally used by First Nations peoples to treat tuberculosis. Extracts made from Heracleum maxi...