AIM This randomized, controlled, clinical study was designed to evaluate the adjunctive effect of calcium sulphate grafts on the surgical treatment of through and through periradicular lesions. METHODOLOGY Twenty patients each with one tooth showing evidence radiologically of a periradicular lesion wider than 10 mm, with lack of both buccal and lingual cortical bony plates and an indication f...

OBJECTIVE Recent work has focussed on schizophrenia as a 'deficit' state but little attention has been paid to defining illness plasticity in terms of symptomatic remission. METHOD A qualitative review of a recently proposed concept of remission [N.C. Andreasen, W.T. Carpenter Jr, J.M. Kane, R.A. Lasser, S.R. Marder, D.R. Weinberger (2005) Am J Psychiatry 162: 441] is presented. RESULTS The...

microRNAs represent the best described class of small RNAs (21-23nt) and have been shown to function as post-transcriptional regulators of gene expression. The high relative stability of microRNA in common clinical samples such as serum/plasma, urine and other biofluids, and the ability of micro RNA expression profiles to accurately classify discrete tissue types and specific disease states hav...

In a previous paper (Smellie, McIndoe, Logan, Davidson & Dawson, 1953) we have discussed the incorporation of radioactive phosphorus (82p) into the deoxyribonucleic acid (DNA) of the cell nucleus of rabbit liver and into the ribonucleic acid of the nucleus (nRNA) and of the various cytoplasmic fractions (cRNA) at different times after administration of the isotope. Asmightbe expected in a non-p...

Several brain abnormalities have been claimed in schizophrenia, but the pathophysiology of the disorder remains unclear. Of the many reported findings, two lines of research data have emerged as particularly consistent, involving pathology of dorsolateral prefrontal cortex and dysregulation of the dopamine system. Abnormal dorsolateral prefrontal cortical function has been implicated in a numbe...

This paper addresses the development of an eco-friendly Ultra-High Performance Concrete (UHPC) with efficient cement and mineral admixtures uses are investigated. The modified Andreasen & Andersen particle packing model is utilized to achieve a densely compacted cementitious matrix. Fly ash (FA), ground granulated blast-furnace slag (GGBS) and limestone powder (LP) are used to replace cement, a...

Genius and madness have long been thought to be intimately entwined. However, the idea remains controversial: some rail against the stereotype of the mad scientist or the crazy artist (e.g., Schlesinger, 2009, 2012), while others note higher incidences of mental illness amongst creative geniuses, including prize-winning authors, visual artists, and poets (e.g., Andreasen, 1987; Kaufman, 2000-20...

Disorders of consciousness and the self are at the forefront of schizophrenia symptomatology. Patients are impaired in feeling themselves as the authors of their thoughts and actions. In addition, their flow of consciousness is disrupted, and thought fragmentation has been suggested to be involved in the patients' difficulties in feeling as being one unique, unchanging self across time. Both im...

The objective of this study was to examine the predictive validity of the remission criteria proposed by Andreasen et al in first-episode patients responding to antipsychotics. Antipsychotic responsive patients with first-episode schizophrenia showing symptom remission (n = 60) were compared with patients who did not fulfill the proposed criteria (n = 65). Outcome in terms of symptom severity, ...

Decreased serum folate levels of patients receiving anticonvulsants have been well documented (Klipstein 1964; Reynolds 1968; Dahlke and Mertens-Roeslei 1967; Horwitz et al. 1968; Jensen and Olesen 1969; Houben et al. 1971). At present time, however, the mechanism for this abnormality seems to be remaining unsolved, even though several attractive theories have been advanced, that is, an increas...