CONTEXT Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human tumors; it is characterized by chemoresistance, local invasion, and distant metastases. ATC is invariably fatal. OBJECTIVE The aim was to study the role of TWIST1, a basic helix-loop-helix transcription factor, in ATC. DESIGN Expression of TWIST1 was studied by immunohistochemistry and real-time PCR in normal thy...

personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. as life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. cancer is a disease that the response to treatment varies from one person...

Introduction/Objective. Alcohol abuse influence on developing thyroid cancer is controversial. While some studies consider it a protective factor, others deny any impact cancer. The objective of the paper was to establish possible link between alcohol and certain types cancers. Methods. retrospective study included 502 patients with control group 600 benign forms diseases (e.g. nodular, multino...

this study was undertaken to define the epidemiological aspects of thyroid carcinoma in iran, an area of endemic iodine deficiency nearly until recently. the tehran cancer institute data system registry (tcidsr) was used to identify patients with different histological types of thyroid cancer (tc) in iran. data were analyzed from 438 thyroid cancer cases identified by the tcidsr in 1998-99. dis...

Thyroid carcinoma is the most common malignant endocrine neoplasia. Differentiated thyroid carcinomas (DTCs) represent more than 90% of all thyroid carcinomas and comprise the papillary and follicular thyroid carcinoma subtypes. Anaplastic thyroid carcinomas correspond to less than 1% of all thyroid tumors and can arise de novo or by dedifferentiation of a differentiated tumor. The etiology of ...

Thyroid surgeons are becoming increasingly more aware of a histologically distinct subset of thyroid carcinoma whose classification falls between well-differentiated and anaplastic carcinomas with respect to both cell differentiation and clinical behavior. This subtype of tumors has been categorized as poorly differentiated or insular carcinoma, based on its characteristic cell groupings. Altho...

BACKGROUND The catalytic component of telomerase, human telomerase reverse transcriptase (hTERT) has been found to be reactivated in immortalized cell lines and considered as a diagnostic marker for malignancy in different body tissues. AIM OF WORK Therefore we thought to determine whether hTERT gene detection could serve as an adjunct in the diagnosis of thyroid lesions together with evaluat...