The physiological function of neurotransmitter transporter proteins like the serotonin transporter (SERT) is reuptake of neurotransmitter that terminates synaptic serotoninergic transmission. SERT can operate in reverse direction and be induced by SERT substrates including 5-HT, tyramine and the positively charged methyl-phenylpyridinium (MPP(+)), as well as the amphetamine derivatives para-chl...

Severe and malignant hyperthermia is a frequently reported factor in emergency department (ED) visits and fatalities in which use of amphetamine drugs, such as (+/-)3,4-methylenedioxymethamphetamine (MDMA), (+/-)3,4-methylenedioxyamphetamine (MDA) and (+)methamphetamine (METH), is confirmed. Individuals who use "ecstasy" are also often exposed, intentionally or otherwise, to several of these st...

the aim of this study was to determine the monthly dtr mass load of amphetamine-type compounds in poland as well as an investigation of cyclical behaviour by using time series analysis and especially trends analysis.amphetamine, methamphetamine and mdma (ecstasy) were detected in wastewater samples collected from the main wastewater treatment plant in the city of poznan using liquid chromatogra...

When amphetamine or an analog is administered in repeated high doses, neurochemical deficits in both the dopaminergic and serotonergic systems of selected areas of the brain are observed. Methamphetamine (10 to 15 milligrams per kilogram (mg/kg)), administered every 6 hours for 5 doses, decreases rat tyrosine hydroxylase (TH) activity and dopamine (DA) content in the neostriatum within 18 hours...

Abstract Attention-deficit hyperactivity disorder (ADHD) with its high prevalence is a growing area of concern and research, whereas exact underlying pathophysiology remains unknown. Behavioral therapy multiple medications include methylphenidate, atomoxetine, amphetamines while trigeminal nerve stimulator (TNS) the first medical device in ADHD FDA approval. The aim this article to evaluate lat...

Self-administered questionnaire was given to a sample of 105 interns and house officers working in Govt. Medical College, Jammu. Questionnaire was designed to obtain information about socio-demographic characteristics, the frequency of non-medical drug use during the last one year and to enquire about "reasons" for drug intake. It was found that drugs commonly used were alcohol, tobacco, tranqu...

The purpose of this research was to study the demography, financial status, social status, knowledge of amphetamines, perceived harmfulness of amphetamines, and life skills in the prevention of drug abuse in adolescents. The factors leading to drug use among young people were also studied. The study group was composed of 354 subjects aged 12 to 22 years, living in 2 slums in Bangkok. The resear...