conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...

we have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. the results show that the point of highest concentration of the c subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 ilg/ inl and 10µg/ml theophylline, this is shifted to i.s and 2....

infection with helicobacter pyloriis the most common cause of stomach and duodenal ulcers. about more than 80 % of people are infected with h. pylori in developing countries. h. pyloriuses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of h. pylori. inhibito...

it is now believed that the inhibition of carbohydrate hydrolyzing enzymes (ches) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. therefore, inhibitors of ches can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...

bypassing agents are the most commonly used medicines for the treatment of hemophilia patients with inhibitors. the aim of this study is to identify the cost components of management of bleeding vents in hemophilia patients with inhibitors in iran. this study is a cross-sectional study using a bottom-up approach to determine the cost components of treatment of hemophilia patients with inhibitor...

background & aim:  the aim of this study was to assess the bactericidal effect of three medicinal plant species, including thymus vulgaris, trachyspermum ammi, and mentha aquatica on erwinia carotovora growth. experimental: this research was done in a factorial to completely randomized design with three concentrations, and three replicates on nutrient agar culture medium. results &discu...

furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

resin- dentin interface hydrolysis is one of the greatest problems in restorative dentistry, because of collagenolytic and proteolytic activity of dentin enzymes. the aim of this study was to compare the effect of chx 2% and naocl 5% as rewetting agent on resin-dentin micro tensile bond strength.methods: 45 extracted, human caries-free third molar teeth were collected. after exposing of superfi...

acid extract of solanum tuberosum was tested as corrosion inhibitor for mild steel in 1 m hcl and h2so4 media using different techniques: weight loss (in different temperatures viz., 303, 313 and 323 k), potentiodynamic polarization, electrochemical impedance spectroscopy (eis) and sem techniques. the studies reveal that the plant extract act as good inhibitors in both the acid media and better...