Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...

A 39-year-old woman was diagnosed as having immune thrombocytopenia (ITP) in 1981 in another hospital, and she was well controlled with prednisolone. No other immunosuppressive drugs, such as cyclosporine or azathioprine, were used. In 1997, she was diagnosed as having acute megakaryoblastic leukemia (AML-M7) in another hospital. Blasts showed the absence of peroxidase (POX) and positive platel...

The near horizon limits of M2 and D3 branes probing special holonomy cones give rise to supersymmetric AdS4 × M7 and AdS5 × M5 solutions of D = 11 and type IIB supergravity, respectively, where M7 and M5 are special types of Einstein spaces. Here we will show the existence of consistent Kaluza-Klein truncations of D = 11 and type IIB supergravity on such M7 and M5 down to matter-coupled supergr...

This demonstration introduces the Stride programming language, the Stride IDE, and the Saturn M7 embedded audio development board. Stride is a declarative and reactive domain specific programming language for real-time sound synthesis, processing, and interaction design. The Stride IDE is a cross-platform integrated development environment for Stride. Saturn M7 is an embedded audio development ...

Differentiation-inducing therapy with all-trans retinoic acid significantly improved the outcome in children with acute promyelocytic leukemia (APL). Therefore, use of agents that induce differentiation of leukemic cells in non-APL children appears to be a highly promising therapeutic approach. Based on the experimental studies in mice, we have shown that short-course high-dose methylprednisolo...

While studying Ikaros proteins in childhood acute myeloid leukemia (AML), Ikaros isoform 6 (Ik6) expression was detected in 7 of 10 cases of M4 and M5 leukemia, but in none of the remaining French-American-British subtypes (M2, 8 cases; M7, 6 cases). The spliced Ikaros isoforms 4 to 8 (Ik4-8) suppress the function of full-length Ik1 or Ik2 in a dominant-negative manner, owing to their reduced n...

AIMS To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia. METHODS Cerebrospinal fluid (CSF) samples from patients with acute myelogenous leukaemia (AML) at diagnosis (n = 2) and acute lymphoblastic leukaemia (ALL) at diagnosis (n = 14) were analysed for parvovirus B19 DNA by means of nested polymerase chain reaction...

BACKGROUND Acute myeloid leukemia presenting the MYST3-CREBBP fusion gene is a rare subgroup associated with hemophagocytosis in early infancy and monocytic differentiation. The aim of this study was to define the relevant molecular cytogenetic characteristics of a unique series of early infancy acute myeloid leukemia cases (≤24months old), based on the presence of hemophagocytosis by blast cel...

Among 2333 consecutive patients with myelofibrosis with myeloid metaplasia (MMM) seen at our institution, 91 fulfilled the World Health Organization (WHO) criteria for leukemic transformation (LT). All episodes of LT were myeloid in origin (acute myeloid leukemia [AML]) with all French-American-British (FAB) subtypes represented except M3; the most frequent subtypes were M7 (25.4%), M0 (22.4%),...