A dichloromethane extract from leaves of Searsia pyroides potentiated gamma aminobutyric acid-induced chloride currents by 171.8 ± 54% when tested at 100 µg/mL in Xenopus oocytes transiently expressing gamma aminobutyric acid type A receptors composed of α1β2γ2s subunits. In zebrafish larvae, the extract significantly lowered pentylenetetrazol-provoked locomotion when tested at 4 µg/mL. Active ...

Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors chatecholamines. In the current review, Web Science, PubMed, Scopus Science Direct, were searched to investigate plants effects

Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of m...

A strain of Pseudomonas Jluorescens (ATCC 13430) was isolated which could utilize either pyrrolidine or putrescine as the sole source of carbon, nitrogen, and energy for growth. An investigation of the metabolism of pyrrolidine by this organism (1) suggested Al-pyrroline (I) as the first product of pyrrolidine catabolism followed by y-aminobutyric acid (III). Enzymes which were induced by growt...

The gamma-aminobutyric acid antagonist, bicuculline methiodide (BMI), induces myoclonic seizures in rats when injected into the deep prepyriform cortex at concentrations lower than those that induce convulsions from the amygdala, hippocampus, or neocortex. This observation prompted the suggestion that the deep prepyriform cortex was responsible for seizure generation regardless of the neurotran...