Paracetamol (APAP-Acetaminophen) has been used extensively as antipyretic drug. The purpose of this study was to evaluate the ameliorative role of silymarin or/and Nigella sativa extract against APAP-induced hyperlipidemia in male mice at the biochemical, levels. The mice were divided into seven groups (10/group). The first group was served as control. While, the second group was treated with d...

The use of natural antioxidants as mitigating agents has become prevalent. Garlic (Allium sativum) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the antimalarial drug induced hepato-toxicity. Artesunate is being used a...

The present investigation was an attempt to evaluate the possible ameliorative effect of Eclipta alba on carbon tetrachloride (CCl4) – induced lipid peroxidation in liver of mice in vitro. Antioxidant activity of medicinally important plant Eclipta alba was determined by DPPH – radical scavenging activity. Liver tissue was collected from healthy Swiss albino female mice weighing 30-35 gm. Liver...

India is one of the endemic areas where control of malaria has become a formidable task. Artesunate is the current antimalarial drug used to treat malaria, especially chloroquine resistant. The objective of the present study was to investigate the dose-dependent effect of oral administration of artesunate on the oxidative parameters in testes of adult male Swiss albino mice and ameliorative eff...

During gestation and lactation, the experimental mice dams received one of the following treatments: (a) diet free of pesticide; (b) diet enriched with endosulfan (END); 30.0 µg kg(-1); (c) diet free of pesticide + oral vitamin E (α-tocopherol; 200 mg kg(-1) per mouse); and (d) diet enriched with END (30.0 µg kg(-1)) + oral vitamin E (200 mg kg(-1) per mouse). At weaning, pups and dams were kil...

BACKGROUND Nephropathy, a chronic progressive kidney disease often characterized by glomeruli scarring and sclerosis, is a major complication of diabetes mellitus. Development of nephropathologic lesions has been shown to be associated with suppressed AKT phosphorylation and elevated level of apoptosis. Moreover, it has been established that the TRB3 gene is capable of inhibiting AKT phosphoryl...

Article history: Received on: 20/10/2013 Revised on: 24/11/2013 Accepted on: 05/01/2014 Available online: 30/01/2014 The present study has designed to evaluate the combined effect of rutin (RT) and silymarin (SM) on oxidative stress in STZ-induced diabetic rats. Diabetic rats exhibited increased serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatas...

Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (ABM), and their combination (MET+ABM), and to evaluate the ameliorative effect of zinc co-administration. Three groups of rats were designated for ...

This paper is an exploratory analysis of the efficacy of parliamentary representation as a means to moderate ethnic conflict in new democracies. We agree with many others that the interests of an ethnic minority group are better protected when the group has access to decision makers, can block harmful government policies, and can veto potentially damaging decisions. Parliamentary representation...

OBJECTIVE The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. MATERIALS AND METHODS In the present study, arsenic in the form of sodium arsenite was administered orally ...