High-altitude long-term hypoxia (LTH) is known to induce pulmonary arterial smooth muscle cell (PASMC) proliferation in the fetus, leading to pulmonary arterial remodeling and pulmonary hypertension of the newborn. The mechanisms underlying these conditions remain enigmatic however. We hypothesized that epigenetic alterations in fetal PASMC induced by high-altitude LTH may play an important rol...

the prevalence of the disease (pretest probability) in the study population. Current data report the presence of Ex-PHtn in COPD, heart transplantation, susceptibility to high-altitude pulmonary edema, congenital heart disease, thromboembolic pulmonary hypertension, scleroderma, and relatives of patients with pulmonary arterial hypertension. However, the actual prevalence and clinical value (ea...

We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at high altitude (HA, 3,600 m) or low altitude (LA, 520 m). Cardiopulmonary variables were recorded in vivo, with and without SOC blockade by 2-aminoethyldiphenylborinate (2-APB), during basal or acute ...

Acute high-altitude illnesses are of great concern for physicians and people traveling to high altitude. Our recent article “Acute Mountain Sickness, High-Altitude Pulmonary Edema Cerebral Edema, a View from the High Andes” was questioned by some sea-level experts. As result this, we answer observations further explain our opinion on these diseases. (HAPE) can be better understood through Oxyge...

pulmonary hypertension (ph) is an important cause of heart failure in chronic obstructive pulmonary disease (copd). the pro brain natriuretic peptide n-terminal (nt-probnp) has been suggested as a noninvasive marker to evaluate ventricular function. however, there is no evidence to support the use of nt-probnp in monitoring the benefits of vasodilators in copd induced ph. thus, we used nt-probn...

Heath, D., Smith, P., Wifliams, D., Harris, P., Arias-Stella, J, and Kriiger; H. (1974). Thorax, 29, 463-471. The heart and pulmonary vasculature of the llama (Lama glama). A qualitative and quantitative histological study was made of the pulmonary trunk and muscular pulmonary arteries of a male and a pregnant female llama born and living at an altitude of 4,720 m above sea-level in the Peruvia...

Perinatal exposures exert a profound influence on physiological function, including developmental processes vital for efficient pulmonary gas transfer throughout the lifespan. We extend the concept of developmental programming to chronic mountain sickness (CMS), a debilitating syndrome marked by polycythemia, ventilatory impairment, and pulmonary hypertension that affects ∼10% of male high-alti...

hemochromatosis, especially with cardiac and liver problem, is rare in iran. we report a young female with pulmonary hypertension and abnormal liver function tests due to non hfe- related hemochromatosis.

High-altitude pulmonary edema is a life-threatening condition occurring in predisposed but otherwise healthy individuals. It therefore permits the study of underlying mechanisms of pulmonary edema in the absence of confounding factors such as coexisting cardiovascular or pulmonary disease, and/or drug therapy. There is evidence that some degree of asymptomatic alveolar fluid accumulation may re...