نتایج جستجو برای: alteplase
تعداد نتایج: 6831 فیلتر نتایج به سال:
T he results of the third European Cooperative Acute Stroke Study (ECASS 3) show that patients with acute stroke, who could not make it to the hospital within the 3-hour treatment time window, still have a chance to benefit from intravenous alteplase if they can be treated within 4.5 hours of stroke onset. 1 They will not be exposed to an increased risk of brain hemorrhage compared with patient...
BACKGROUND AND PURPOSE Downstream microvascular thrombosis (DMT) is known to be a contributing factor to incomplete reperfusion in acute ischemic stroke. The aim of this study was to determine the timing of DMT with intravital imaging and to test the hypothesis that intravenous alteplase infusion could reduce DMT in a transient middle cerebral artery occlusion (MCAO) rat stroke model. METHODS...
BACKGROUND Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However, patients with early ischaemic signs could be at increased risk of haemorrhage after alteplase treatment, and little information is available about whether pre-existing structural signs, which are common in older patients, affect response to alte...
This study evaluated the safety and efficacy of alteplase in catheter-directed treatment for peripheral arterial and venous thrombosis and considered the optimal dosing regimen. Forty-four patients (49 encounters) underwent transcatheter therapy using alteplase between January and November 1999. The most common indications for thrombolysis were peripheral arterial occlusion (PAO) and venous thr...
BACKGROUND Reteplase (recombinant plasminogen activator), a mutant of alteplase tissue plasminogen activator, has a longer half-life than its parent molecule and produced superior angiographic results in pilot studies of acute myocardial infarction. In this large clinical trial, we compared the efficacy and safety of these two thrombolytic agents. METHODS A total of 15,059 patients from 807 h...
BACKGROUND AND PURPOSE Thrombectomy, primarily with stent retrievers with or without adjunctive aspiration, provided clinical benefit across multiple prospective randomized trials. Whether this benefit is exclusive to stent retrievers is unclear. METHODS THERAPY (The Randomized, Concurrent Controlled Trial to Assess the Penumbra System's Safety and Effectiveness in the Treatment of Acute Stro...
Two patients with acute occlusion of the middle cerebral artery (MCA) were treated with intravenous alteplase. Neurovascular monitoring, which was performed simultaneously via transcranial sonography, enabled precise documentation of MCA recanalization. This information was used to tailor the dosage and duration of alteplase treatment. Sonographic information concerning the arterial segments in...
The outcome of ischemic stroke is related to the volume of brain that is infarcted, and the volume of infarction is directly related to the time to reperfusion. In an anterior circulation, large-vessel ischemic stroke 1.9 million neurons are lost every minute. Treatment efficacy is dependent on time to treatment initiation. Acute ischemic stroke is treated medically with the administration of i...
PURPOSE Bleeding is the major side effect of thrombolysis with alteplase (tissue plasminogen activator, t-PA) used for the treatment of acute ischemic stroke. Life-threatening intracranial, retroperitoneal, gastrointestinal, respiratory, and genitourinary bleeding can occur with the use of t-PA. Vitreo-retinal bleeding in the context of acute ischemic stroke treatment has not been reported in t...
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