نتایج جستجو برای: alpha thalassaemia
تعداد نتایج: 203579 فیلتر نتایج به سال:
background: until now, trimodal distribution of hbs has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. the rbc indices reduce as alpha-globin genes reduce in sickle cell trait (sct) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical course of the patien...
α-Thalassaemia is the most common inherited disorder of Haemoglobin (Hb) production in southeast Asia, resulting from deficient synthesis of the α-globin chain component of the haemoglobin molecule due to deletion or inactivation of one or more of the normal four alpha-chain genes. The severity of the condition depends on the number of genes inactivated. The severest form is Hb Barts hydrops fe...
The effectiveness of the one tube method of osmotic fragility with three buffered solutions (0.32% saline, 0.36% saline, and tyrode) as a screening test for beta-thalassaemia trait was evaluated in several groups of subjects from Greece, Yugoslavia, and Thailand. The results clearly demonstrated that 0.36% saline is the most sensitive and effective solution since it could detect 96 to 100% of h...
Over a period of one year the blood samples collected for phenylketonuria testing from 7691 Manchester newborns were screened by haemoglobin electrophoresis. An abnormality was detected in 47 (0-61%) of the babies. No cases of homozygous haemoglobinopathy were found. The overall incidence of sickle-cell trait was 0-38%, but for the Black population it was 10%. Four Black babies and one White ba...
Polymorphisms of the haptoglobin (HP) gene and deletions in alpha-globin gene (alpha-thalassaemia) are common in malaria-endemic Africa. The same region also has high incidence rates for childhood acute seizures. The haptoglobin HP2-2 genotype has been associated with idiopathic generalized epilepsies and altered iron metabolism in children with alpha-thalassaemia can potentially interfere with...
The α-globin genes were studied in nine families with unexplained hypochromic anaemia and in 167 patients with HbE β thalassaemia in Sri Lanka. As well as the common deletion forms of α(+) thalassaemia three families from an ethnic minority were found to carry a novel form of α(0) thalassaemia, one family carried a previously reported form of α(0) thalassaemia, --(THAI), and five families had d...
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