Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner a...

Natural remedies from medicinal plants are considered to be effective and safe alternative treatments for diabetes mellitus. Decoction prepared from the leaves of I. frutescens is used to alleviate the symptoms of diabetes mellitus in folk medicine. The present study was designed to evaluate the anti-diabetic and antihyperlipidemic effects of the polyphenolic extract (PPE) of I. frutescens leav...

Since it is known that alloxan will react with many substances, and because preliminary unpublished work in this laboratory suggested that ascorbic acid potentiated the action of alloxan, the effect of ascorbic acid on the diabetogenic action of alloxan was investigated. Experimental. Hooded rats weighing approximately 250 g were used in this study. These animals were fed Purina Dog Chow during...

BACKGROUND The present study was planned to observe the hypoglycaemic effect of the 'Compound recipe' a combination of traditional medicinal plants in normal and alloxan induced diabetes mellitus. This study was performed to study the possible role of indigenous medicinal plants in the regeneration of pancreatic beta-cells and in treatment of insulin dependent diabetes mellitus. METHODS The '...

To examine whether islet amyloid polypeptide (IAPP), other than through amyloid formation, may be of importance in diabetes pathogenesis, IAPP-deficient mice (IAPP(-/-)) were challenged with alloxan (day 0). Diabetes in IAPP(-/-) mice was more severe at day 35, indicated by greater weight loss; glucose levels were higher in alloxan-treated IAPP(-/-) mice, whereas insulin levels were lower, indi...

We studied the incidence of electron microscopic pathological patterns of the alveolar septum observed 30 min after induction of pulmonary edema by dextran-70 infusion (6 dogs, dextran group) and by alloxan injection (6 dogs, alloxan group). For comparable amounts of extravascular lung water in both dextran and alloxan groups, which were twice as much as control group (6 dogs), we characterized...

Medicinal plants have played an important role in the treatment and prevention of diseases since ancient times. They are also potential sources of nutrients and drugs. This study evaluated Achyranthes aspera ethanolic extracts for their in vitro antioxidant activity and anti-hyperglycemic effects on alloxan-induced diabetic mice. Diabetes was induced in Swiss albino mice through intra-peritonea...

Oxidative stress occurs in diabetic patients and experimental models of diabetes. The ability of L-arginine to ameliorate oxidative stress after treatment with alloxan was investigated in rats. Adult male rats were injected intraperitoneally with multiple doses of alloxan to produce experimental oxidative stress characteristic of diabetes mellitus. The rats were maintained in this state for eig...

background & objectives: alloxan & streptozotocin are used for inducing diabetic models. their combination has been used to reduce the individual chemical dosage and minimize the side effects. present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of alloxan-stz cocktail in rabbits. methods: new zealand white rabbits, 1-1.5 kg body weight, were a...