Although allergic contact dermatitis (ACD) due to corticosteroids is a well-known and relatively common phenomenon, the systemic administration of corticosteroids only rarely produces skin reactions (systemic contact dermatitis [SCD]). We present the case of a patient with ACD to various corticosteroids, and who subsequently developed SCD to multiple systemic corticosteroids. A 47-year-old man ...

Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates ce...

To the Editor: Intralesional triamcinolone acetonide (TA) injections can rapidly and effectively treat severe localized dermatitis. However, these treatments are associated with adverse effects such as dermal atrophy, hypopigmentation, capillary dilation, and Cushing syndrome. These adverse effects may be attributable, in part, to the large doses of TA required to obtain the desired outcome. Th...

contact dermatitis is an inflammatory reaction of the skin and mucosa to either external or internal factors. it can be divided to two forms of irritant contact dermatitis and allergic contact dermatitis. nickel is one of the most common materials that causes allergic contact dermatitis and is widely used in orthodontic appliances. the inflammatory reaction to this metal in orthodontics is usua...

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To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the sensitization phase, rather than in the elicitation phase, dramatically alleviated the symptoms of allergic inflammation. We hypothesized that AS-IV exerts its anti-allergy effects by regulating the production of key pro-...

BACKGROUND Allergic contact dermatitis (ACD) is a common clinical condition in industrialized countries and often causes occupational diseases. Animal model of contact sensitivity (CS) is commonly used to study ACD in mice and can be induced by skin application of haptens. It has been previously shown that CS is mediated by CD4(+) or CD(8+) T effector cells. More recently it was found that also...

Background; There is still controversy as to whether atopic dermatitis (AD) susceptible allergic contact (ACD). no report from Japan on allergens in which patients with AD are prone ACD. Objectives; The purpose of this study was examine the relationship between Japanese and ACD by comparing positive rates various antigens without a history using our patch test data. Materials/Methods; This sing...

BACKGROUND Chemicals used in leather tanning, rubber processing, and/or adhesives are the most often-cited culprits in footwear dermatitis. Patch testing patients with suspected shoe dermatitis is essential for diagnosis and management. OBJECTIVES The four goals for this study were to (1) determine the frequency of allergens associated with a shoe source in North American Contact Dermatitis G...

The cytokine IL-9, derived primarily from T-helper 9 (Th9) lymphocytes, promotes expansion of the Th2 subset and is implicated in the mechanisms of allergic asthma. We hypothesize that IL-9 also has a role in human allergic contact dermatitis (ACD). To investigate this hypothesis, skin biopsy specimens of positive patch-test sites from non-atopic patients were assayed using quantitative PCR and...