Despite tremendous progress in the understanding and management of hypertension, control of elevated blood pressure (BP) in the general hypertensive population remains unsatisfactory, with only an approximate one third of patients 1 achieving the recommended BP goals. Consequently, cardiovascular risk as a result of target organ damage, notably in the heart, kidneys and brain remain high among ...

Vanja Klepac-Ceraj,1* Katherine P. Lemon,2 Thomas R. Martin,3 Martin Allgaier,4 Steven W. Kembel,5 Alixandra A. Knapp,3 Stephen Lory,1 Eoin L. Brodie,6 Susan V. Lynch,4 Brendan J. M. Bohannan,5 Jessica L. Green,5 Brian A. Maurer7 and Roberto Kolter1 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA. Divisions of Infectious Diseases and Respiratory ...

8 Secondary ion mass spectrometry (SIMS) U-Pb ages of Ca-phosphates from four texturally 9 distinct breccia samples (72255, 76055, 76015, 76215) collected at the Apollo 17 landing site 10 were obtained in an attempt to identify whether they represent a single or several impact 11 event(s). The determined ages, combined with inferences from petrologic relationships, may 12 indicate two or possib...

The morphological organization of monoamine (MA)-containing neurons in the brain of the longnose gar (Lepisosteus osseus) was studied by means of fluorescence histochemical methods. In this species, one of the few living representatives of the holostean group of actinopterygian fishes, by far the largest number of MA cells is found within the preoptico-hypothalamic complex. Multitudinous small-...

Caffeine modifies vascular/cardiac contractility. Embryonic exposure to caffeine altered cardiac functions in offspring. This study determined chronic influence of prenatal caffeine on vessel functions in offspring. Pregnant Sprague-Dawley rats (5-month-old) were exposed to high dose of caffeine, their offspring (5-month-old) were tested for vascular functions in mesenteric arteries (MA) and io...

The complexation reactions between Mg2+, Ca2+, Sr2+ and Ba2+ metal cations with 15-crown-5 (15C5) were studied in acetonitrile (AN)-methanol (MeOH) binary mixtures at different temperatures using conductometric method. 15C54 forms 1:1 complexes with Mg2+, Ca2+ and Sr2+ cations in solutions. The Ma2+ cati...

In high-multiplicity infection of human fibroblasts, human cytomegalovirus of WI-38 human diploid cells produced early cell rounding 6 to 24 h after inoculation. This early cell rounding was caused only by inoculation with infectious virions. Inhibitors of protein synthesis, but not DNA inhibitors, prevented this cytopathic effect. Apparently, a new protein is synthesized in infected fibroblast...

Hominin fossil evidence in the Turkana Basin in Kenya from ca. 4.1 to 1.4 Ma samples two archaic early hominin genera and records some of the early evolutionary history of Paranthropus and Homo. Stable carbon isotopes in fossil tooth enamel are used to estimate the fraction of diet derived from C3 or C4 resources in these hominin taxa. The earliest hominin species in the Turkana Basin, Australo...