Alkaloid profile of the aerial parts of Genista sandrasica Hartvig & Strid. (Fabaceae) growing in Turkey was studied by capillary gas chromatography-mass spectrometry (GC-MS). Ten quinolizidine alkaloids were identified in the alkaloid extract of G. sandrasica. The main alkaloids were: sparteine (13.68%), Nacetylcytisine (6.48%), 13-methoxylupanine (13.12%), anagyrine (40.49%) and baptifoline (...

Article history: Received on: 05/11/2012 Revised on: 29/11/2012 Accepted on: 18/12/2012 Available online: 28/02/2013 Anisodus acutangulus hairy roots were grown in N6 medium which was optimal for growth and alkaloid production. The cell biomass and alkaloid yield reached 2.7 g l and 3.9 mg l (dry weight) respectively in sucrose medium, higher than those obtained in other carbon source media. 90...

The antifungal activity of aqueous, petroleum ether, benzene, chloroform, methanol and ethanol extracts and alkaloid extract of Prosopis juliflora (Sw.) DC. leaves (Mimosaceae) was evaluated for antifungal activity by poisoned food technique against Alternaria alternata a causal organism of brown spot of tobacco. Aqueous extract recorded highly significant antifungal activity at 24% concentrati...

A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 μg/mL), Anopheles sin...

A new method is described in which the Salkowski reaction is used for the rapid selection of alkaloid-producing mutants of the ergot fungus. This method was used to investigate the influence of a second mutation with N-methyl-N'-nitro-N-nitrosoguanidine (NTG) on various mutants selected by a preliminary NTG mutation of Claviceps sp. strain SD 58. Three groups of mutants were used: high alkaloid...

A precursor application system was developed to allow the study of Erythrina alkaloid formation in Erythrina crista-galli. Fruit wall tissue of this species was recognized as the major site of alkaloid biosynthesis. The application of radioactively and 13C-labelled potential precursors showed that the hitherto assumed precursor (S)-norprotosinomenine was not incorporated into the Erythrina alka...

The alkaloid ageladine A, a pyrrole-imidazole alkaloid isolated from marine Agelas sponges shows fluorescence in the blue-green range during excitation with UV light with the highest absorption at 370 nm. The fluorescence of this alkaloid is pH dependent. Highest fluorescence is observed at pH 4, lowest at pH 9 with the largest fluorescence changes between pH 6 and 7. Ageladine A is brominated,...

The aim of this work was to improve understanding of the regulation of alkaloid biosynthesis in two Solanaceae plants, Nicotiana tabacum (tobacco) and Hyoscyamus muticus (Egyptian henbane). In order to map the biosynthetic genes involved in the tobacco alkaloid pathway, a functional genomics-based technology was established by combining genome-based transcript profiling (cDNA-AFLP) with targete...

A new approach for the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin has been developed using a palladium(ii)-catalysed MOM-ether directed Overman rearrangement to establish the second stereogenic centre and a cross metathesis reaction to generate the carbon backbone. In the final stage, a one-pot acid mediated deprotection of aldehyde, guanidine and hydroxyl grou...

Objective: The current study was designed to explore the hepatoprotective activity of Phyllanthus niruri (PN) alkaloid fraction in induced hepatitis in rats. Methods: The rats are divided into 5 groups as per the experimental design. Pre alkaloid treatment of PN was given to the hepatitis rats for 21 d. After completion of the treatment, the serum was collected, and biochemical analysis was car...