Floating calcium alginate beads based on gas-generation technique often suffer from poor drug encapsulation and rapid drug release in the acidic environment of the stomach. To overcome the above mentioned demerits, in the present study we have evaluated the influence of formulation factors such as incorporation of mixtures of gasgenerating agents (NaHCO3 and CaCO3), incorporation of gelatin typ...

Microencapsulating stem cells in injectable microbeads can enhance delivery and localization, but their ability to act as growth factor production sources is still unknown. To address this concern, growth factor mRNA levels and production from alginate microbeads with encapsulated human adipose stem cells (ASC microbeads) cultured in both growth and chondrogenic media (GM and CM) were measured ...

Cell encapsulation technology raises great hopes in medicine and biotechnology. Transplantation of encapsulated pancreatic islets represents a promising approach to the final cure of type 1 diabetes mellitus. Unfortunately, long-term graft survival and functional competence remain only partially fulfilled. Failure was often ascribed to the lack of biocompatibility generating inflammatory respon...

Alginate hydrogels are a commonly used substrate for in vitro 3D cell culture. These naturally derived biomaterials highly tunable, biocompatible, and can be designed to mimic the elastic modulus of adult brain at 1% w/v solution. Recent studies show that molecular weight alginate affect viability differentiation. The relationship between weight, viscosity ratio G:M monomers is complex, balance...

Sodium alginate, irradiated by Co-60 gamma rays in solid state, elicits plant growth promoting responses in various plants. Irradiated sodium alginate (ISA) was applied as a foliar spray on mint (Mentha arvensis L.) to investigate its effect on plant growth, physiological attributes and herbage yield as well as on content and yield of essential oil and its components (menthol, L-menthone, isome...

UNLABELLED The molecular mechanisms of alginate polymerization/modification/secretion by a proposed envelope-spanning multiprotein complex are unknown. Here, bacterial two-hybrid assays and pulldown experiments showed that the catalytic subunit Alg8 directly interacts with the proposed copolymerase Alg44 while embedded in the cytoplasmic membrane. Alg44 additionally interacts with the lipoprote...

The impact of membrane fouling by natural organic matter (NOM) on the behavior of micropollutants during ultrafiltration (UF) was investigated. Batch experiments with radioactively labeled estradiol and ibuprofen in the presence of NOM model compounds (alginate, Nordic aquatic and Aldrich humic acid) were performed using a hydrophilic and a hydrophobic membrane. The results indicate that the im...

Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, Draget, & Vårum, 2013). The purpose of the present study was to characterize alginate gels crosslinked with calcium and chitosan oligomers. Using two different alginates of simila...

Herein, it is aimed to highlight the importance of process parameter choice during directional solidification polymer solutions, as they have a significant influence on pore structure and orientation. Biopolymer solutions (alginate chitosan) are directionally frozen, while systematically varying parameters such external temperature gradient, overall system, temperatures cooling surfaces. In add...