PURPOSE To compare the efficacy and safety of single (tamsulosin) and double dose (tamsulosin + alfuzosin) alpha-blocker therapy for treating catheterized patients with acute urinary retention (AUR) due to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS Seventy patients with AUR due to BPH were catheterized and randomized into two groups: the single dose group (0.4 mg tamsulosin, 35...

OBJECTIVE To critically evaluate the efficacy of an α-blocker in improving ureteral-stent-related symptoms and preliminarily investigate the difference between different types of α-blockers. METHODS Relevant randomized controlled trials were identified through searching PubMed, the Cochrane Library, Embase, and other sources. After quality assessment and data abstraction, direct comparison ba...

We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and dissociation kinetics of [(3)H]tamsulosin for recombinant human α(1)-adrenocepto...

Since intraoperative floppy iris syndrome (IFIS) was first described in 2005, its association with the systemic alpha-1 adrenergic antagonist, tamsulosin (Flomax®, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT), has become well established [1-7]. The clinical manifestations of IFIS complicating cataract surgery are poor preoperative pupil dilation, iris billowing and prolapse, and ...

OBJECTIVES We have assessed the kinetics of drug release in relation to the full or partial hydration and swelling of matrices under standard and modified United States Pharmacopeia (USP) apparatus II using a novel index, defined as the symmetrical shape factor. The symmetrical shape factor describes the regularity of the hydration rate of the matrix perimeter relative to its central regions. ...

benign prostatic hyperplasia generally affects males above fourty years of age and has significant effect in overall quality of life (qol). this is one of the cause of millions of dollors in healthcare expenditure. alpha one adrenoreceptor blockers are frequently used for the benign prostatic enlargement because of their significant effect on storage and voiding symptoms, qol, flow rate and pos...