نتایج جستجو برای: akt pathway
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Dear Editor;
 We read with interest the article titled “CYB mtDNA mutations and expression status of genes in PI3K/AKT/mTOR signaling pathway patients schizophrenia” published Cukurova Medical Journal by Dirican et al.
The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members this serve as biomarkers and targets systemic therapy. Tissue primary from treatment-naïve PeCa patients was used tissue microarray analysis. Immunohistochemical staining performed with antibodies against AKT, pAKT, mTOR, pmTOR, pS6, pPRAS, p4EBP1, S6K1 pp70S6...
UNLABELLED Effective oncoprotein-targeted therapies have not yet been developed for ovarian cancer. To explore the role of PI3 kinase/AKT signaling in this disease, we performed a genetic and functional analysis of ovarian cancer cell lines and tumors. PI3K pathway alterations were common in both, but the spectrum of mutational changes differed. Genetic activation of the pathway was necessary, ...
Glycerol 3-phosphate dehydrogenase 1 (GPD1) acts as a tumor suppressor in various types of cancer. However, the mechanisms GPD1 anti-tumor remain unclear breast This study aims to explore function and clinical relevance We confirmed that inhibited ability proliferation, migration, invasion overexpression cancer cells by CCK-8, wound healing, Transwell assays, respectively. found activated lipid...
OBJECTIVE The signaling pathways mediating proliferation and apoptosis in vascular smooth muscle cells (VSMC) are not well established. It has previously been shown that activation of the phosphoinositide 3-OH kinase (PI3K)/Akt pathway or the ERK 1/2 pathway can mediate anti-apoptotic function in different cell types. This study determined the specific contribution of the PI3K/Akt and ERK pathw...
Porcine epidemic diarrhea virus (PEDV) has recently caused high mortality in suckling piglets with subsequent large economic losses to the swine industry. Many intracellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, are activated by viral infection. The PI3K/Akt pathway is an important cellular pathway that has been shown to be required for virus replic...
The purpose of this study was to determine the role Oxidized Low Density Lipoprotein (OX LDL) promotes insufficient autophagy and apoptosis ovarian granulosa cells through regulation Reactive Oxygen Species (ROS) mediated PI3K Akt/mTOR pathway.
Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by recognizing the proteins in this pathway. The st...
Purpose: To study the effects of anisodamine (Ad) combined with lidocaine (Ldc) on myocardial ischemia-reperfusion injury (MIRI) in rats, and its correlation PI3K/AKT signaling pathway.Methods: A total 70 healthy rats were randomly divided into S group, M Ad Ldc + LY group. The cardiac hemodynamic indices each group determined, area infarction measured. Serum biochemical also determined. Furthe...
Abstract Medulloblastoma, an embryonal tumor of the cerebellum, is one most frequent malignant brain tumors. Despite increasing use genetic variation in treatment stratification, high-risk patients characterized by light meningeal spread, TP53 mutations, or MYC amplification still have poor survival. Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling important ...
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