BackgroundHER2 is an important predictive biomarker of HER2-targeted therapies for breast cancer. Reliable HER2 testing essential clinical practice, but immunohistochemistry (IHC) staining results are susceptible to considerable interobserver variations.MethodsWhole-slide images (WSI) pretreatment IHC- and H&E-stained slides, clinicopathological data were obtained from stage I – III, HER2-posit...

background: national institute of environmental health sciences (niehs) scientists shows that long-term exposure to air pollutants increases the risk of respiratory diseases such as allergies, asthma, chronic obstructive pulmonary disease, and lung cancer. children and the elderly are particularly vulnerable to the health effects of ozone, fine particles, and other airborne toxicants. air pollu...

Background: Burn patients are susceptible to healthcare-associated infections. Contaminated surfaces play a role in microbial transmission. This study aimed quantify the degree of contamination burns theatre fomites during routine clinical use. Methods: The Patslide Patient Transfer Board (PAT slide) and operating table were investigated using two methods—bacterial swabs culture viable organism...

Dissolved noble gases in groundwater are used to reconstruct paleotemperature, but also yield information about "excess air", a component of dissolved gases in excess of solubility equilibrium, derived from dissolution of trapped air in the ground. A good characterization of the excess air component is necessary not only to obtain reliable noble gas temperatures, but also to investigate the pot...

Recent developments of efficient propagators, operations and creation methods for MDDs allow us to directly build efficient MDD-based models, without the need of intermediate data structures. In this paper, we make another step in this direction by defining efficient methods to handle cost and soft versions of the MDD constraint. First, we improve the existing algorithms, then we propose to per...

ARTERIAL OXYCEN TENSIONS are reduced in the postoperative patient breathing air. This was studied by Gordh in 19581 and by Nunn and Payne in 1962 -0 and was found to occur, despite normal ventilatory volumes and arterial carbon dioxide tensions, in patients whose preoperative cardiorespiratory status was normal. The purpose of this review is to outline the physiological components and discuss t...