P a t i e n t s 201 patients who were ≥ 18 years of age (mean age 55 y, 56% men) and had objectively confirmed acute VTE (deep venous thrombosis or pulmonary embolism). Exclusion criteria were a baseline international normalized ratio (INR) > 1.4, platelet count < 50 × 109 cells/mL, need for hospitalization, use of oral anticoagulant therapy in the previous 2 weeks, or high risk for major bleed...

194 JADA, Vol. 135, February 2004 R E S E A R C H Background. Light-activated bleaching is a method of tooth whitening. The authors conducted a study to compare the whitening effects and tooth temperature changes induced by various combinations of peroxide bleaches and light sources. Methods. The authors randomly assigned 250 extracted human teeth halves into experimental groups (n = 10). A pla...

Background: Clinical supervision has gained wide recognition in recent years as an essential component of a practitioner’s continuing professional development. However, confusion exists in professional literature regarding the most effective models, styles, processes and methods of clinical supervision. Aim: This article outlines the elements required to establish and sustain an effective clini...

During the past 30 years, aPL have been demonstrated to be pathogenic [1], therefore aPL carriers should be considered at risk for clinical manifestations and managed accordingly. The problem of long-term primary prevention of thrombosis has puzzled physicians [2]. As we know from large cohorts of patients with aPL, the clinical consequences of thrombosis and its recurrence can be severe. The a...

BACKGROUND Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1G93A). Administration of non-targeted glucocorticoids does not significantly alter disease progression, but this may reflect poor CNS delivery. Here, w...

Ultrafast CMR to deliver high volume screening of an at risk thalassemia population in the developing world: preliminary results from the TIC-TOC study (Thailand and UK international collaboration in thalassaemia using an optimised ultrafast CMR protocol) Amna Abdel-Gadir, Yongkasem Vorasettakarnkij, Hataichanok Ngamkasem, Sabrina Nordin, Emmanuel O Ako, Monravee Tumkosit, Pranee Sutcharitchan,...

HBOC-201 may alter lipase and amylase detection on chemistry analyzers using optical methods and affect pancreatic function after trauma. Amylase and lipase measurements were correlated against HBOC-201 to evaluate interference on samples spiked with 0-6g/dL HBOC-201. The detection threshold was 2.5g/dL or none when measured, respectively, on Vitros 250 or Advia 1650 instruments. Amylase and li...